Sci Rep. 2019 Feb 21;9(1):2508. doi: 10.1038/s41598-019-39043-2.
Comparison between chronic hepatitis B patients with untreated immune-tolerant phase vs. those with virological response by antivirals.
Lee HW1,2,3, Kim SU1,2,3, Oidov B1,4, Park JY1,2,3, Kim DY1,2,3, Ahn SH1,2,3, Han KH1,2,3, Kim BK5,6,7.
Author information
1
Department of Internal medicine, Yonsei University College of medicine, Seoul, Republic of Korea.
2
Institute of Gastroenterology, Yonsei University College of medicine, Seoul, Republic of Korea.
3
Yonsei Liver Center, Severance Hospital, Seoul, Republic of Korea.
4
Department of Infectious Diseases, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
5
Department of Internal medicine, Yonsei University College of medicine, Seoul, Republic of Korea. [email protected].
6
Institute of Gastroenterology, Yonsei University College of medicine, Seoul, Republic of Korea. [email protected].
7
Yonsei Liver Center, Severance Hospital, Seoul, Republic of Korea. [email protected].
Abstract
Routine nucleos(t)ide analogs (NUCs) have not yet been recommended for patients with immune-tolerant (IT) phase in chronic hepatitis B virus (HBV) infection. We aimed to evaluate prognosis of patients in untreated IT-phase (UIT group), compared to those in immune-active phase who achieved virological response by NUCs according to guidelines (VR group). Between 2006 and 2012, patients in UIT or VR groups were included. Cumulative risks of HCC and liver-related events (LREs) development were assessed. Furthermore, propensity-score was calculated based upon age, gender, diabetes and liver stiffness. UIT group (n = 126) showed younger age, lower proportion of male gender and lower LS than VR group (n = 641). UIT group had similar 10-year cumulative risks of HCC (2.7% vs. 2.9%, p = 0.704) and LRE (4.6% vs. 6.1%, p = 0.903) development, compared to VR group. When we re-defined UIT group by the lower ALT cut-offs, 10-year cumulative risks of HCC and LRE development were 2.9% and 4.8%, respectively. Using propensity-score matching and inverse probability treatment weighting analysis, similar results were reproduced. UIT group consistently had similar prognosis compared to VR group. Therefore, further large-scale prospective studies in order to verify rationales of routine NUCs in UIT group are still required.
PMID:
30792468
DOI:
10.1038/s41598-019-39043-2
作者: StephenW 时间: 2019-2-24 15:43
Sci Rep.20119 Feb 21; 9（1）：2508。 doi：10.1038 / s41598-019-39043-2。
比较未经治疗的免疫耐受期的慢性乙型肝炎患者与抗病毒药物的病毒学应答。
Lee HW1,2,3，Kim SU1,2,3，Oidov B1,4，Park JY1,2,3，Kim DY1,2,3，Ahn SH1,2,3，Han KH1,2,3，Kim BK5， 6,7。
作者信息
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