二维剪切波弹性成像与九种血清纤维化指标的比较评估慢性

StephenW

Ultraschall Med. 2019 Jan 10. doi: 10.1055/a-0796-6584. [Epub ahead of print]
Comparison of Two-Dimensional Shear Wave Elastography with Nine Serum Fibrosis Indices to Assess Liver Fibrosis in Patients with Chronic Hepatitis B: A Prospective Cohort Study.
Liu J1,2, Li Y2, Yang X1, Ji Y2, Zhang Y2, Wan Q2, Dun G2, Lin S1.
Author information

1
    Infectious Disease, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
2
    Ultrasonography, The Affiliated Baoji Central Hospital, Xi'an Jiaotong University College of Medicine, Baoji, China.

Abstractin English, German
PURPOSE:

 To prospectively assess liver fibrosis with two-dimensional shear wave elastography (2D-SWE) in patients with chronic hepatitis B (CHB) and to compare the performance of this modality with that of serum indices using Scheuer scoring from liver biopsies as the reference standard.
MATERIALS AND METHODS:

 123 patients with CHB underwent 2D-SWE measurements and serological tests between April 2016 and February 2018. The 2D-SWE and serum indices in the diagnosis of liver fibrosis were assessed using receiver operating characteristic (ROC) analyses.
RESULTS:

 The areas under ROC (AUCs) for 2D-SWE, aspartate transaminase-to-platelet ratio index, fibrosis index based on the four factors, Forns score, King's score, FibroIndex, red cell distribution width-to-platelet ratio, Hepascore, type IV collagen, and hyaluronic acid were 0.851, 0.738, 0.701, 0.739, 0.734, 0.711, 0.692, 0.601, 0.640, and 0.522, respectively, in the diagnosis of substantial fibrosis, 0.975, 0.819, 0.792, 0.829, 0.818, 0.807, 0.732, 0.572, 0.676, and 0.544, respectively, in the diagnosis of severe fibrosis, and 0.972, 0.883, 0.862, 0.908, 0.889, 0.918, 0.808, 0.601, 0.807, and 0.775, respectively, in the diagnosis of cirrhosis. The AUCs of 2D-SWE in the diagnosis of substantial fibrosis, severe fibrosis, and cirrhosis were significantly higher than those of the serum indices (p < 0.05).
CONCLUSION:

 2D-SWE is a reliable noninvasive method for the assessment of liver fibrosis in patients with CHB with better diagnostic performance than that of nine serum fibrosis indices.

© Georg Thieme Verlag KG Stuttgart · New York.

PMID:
    30630194
DOI:
    10.1055/a-0796-6584

StephenW

Ultraschall Med。 2019年1月10日doi：10.1055 / a-0796-6584。 [提前打印]
二维剪切波弹性成像与九种血清纤维化指标的比较评估慢性乙型肝炎患者的肝纤维化：一项前瞻性队列研究。
Liu J1,2，Li Y2，Yang X1，Ji Y2，Zhang Y2，Wan Q2，Dun G2，Lin S1。
作者信息

1
    西安交通大学医学院第一附属医院传染病研究室，西安
2
    宝鸡市中心医院附属宝鸡中心医院，宝鸡医学院，宝鸡

摘要英文，德文
目的：

使用二维剪切波弹性成像（2D-SWE）对慢性乙型肝炎（CHB）患者进行前瞻性评估肝纤维化，并使用来自肝脏活组织检查的Scheuer评分作为参考标准，比较该模式与血清指数的表现。
材料和方法：

在2016年4月至2018年2月期间，123名CHB患者接受了2D-SWE测量和血清学测试。使用接受者操作特征（ROC）分析评估了肝纤维化诊断中的2D-SWE和血清指数。
结果：

2D-SWE的ROC（AUCs），天冬氨酸转氨酶与血小板比值指数，基于四因素的纤维化指数，Forns评分，King's评分，FibroIndex，红细胞分布宽度与血小板比率，Hepascore，类型IV胶原和透明质酸分别为0.851,0.738,0.701,0.739,0.734,0.711,0.692,0.601,0.640和0.522，对于实质性纤维化的诊断分别为0.975,0.819,0.728,0.829,0.818,0.807,0.732分别为0.572,0.667和0.544，在严重纤维化的诊断中，分别为0.972,0.883,0.862,0.908,0.889,0.918,0.808,0.601,0.807和0.775，用于肝硬化的诊断。 2D-SWE诊断实质性纤维化，严重纤维化和肝硬化的AUC显着高于血清指标（p <0.05）。
结论：

2D-SWE是一种可靠的非侵入性方法，用于评估CHB患者的肝纤维化，其诊断性能优于9种血清纤维化指标。

©Georg Thieme Verlag KG斯图加特·纽约。

结论：
    30630194
DOI：
    10.1055 / A-0796-6584