韩国极端老年人肝细胞癌的特征和结局。

StephenW

In Vivo. 2019 Jan-Feb;33(1):145-154. doi: 10.21873/invivo.11451.
Characteristics and Outcomes of Extreme Elderly Patients With Hepatocellular Carcinoma in South Korea.
Seo JH1, Kim DH1, Cho E1, Jun CH2, Park SY1, Cho SB1, Park CH1, Kim HS1, Choi SK1, Rew JS1.
Author information

1
    Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea.
2
    Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea [email protected].

Abstract
BACKGROUND/AIM:

The number of elderly patients diagnosed with hepatocellular carcinoma (HCC) has been increasing. But there is no proper management based on age stratification in elderly patients. Therefore, we evaluated the clinical characteristics and outcomes of elderly HCC patients more than 75 years old in South Korea.
PATIENTS AND METHODS:

Five hundred and fifty elderly patients with HCC were enrolled and divided into the oldest-old (age ≥85 years), middle-old (age between 80 and 85 years), and young-old groups (age between 75 and 80 years).
RESULTS:

Fifty-one, 153, and 346 patients were included in the oldest-old (mean age: 87 years), middle-old (mean age: 82 years), and young-old groups (mean age: 77 years), respectively. There was a significantly lower rate of alcohol-related and hepatitis B virus-related diseases in the oldest-old group than in the other groups, whereas there was no significant difference in other characteristics. With increasing age, conservative treatment was predominantly performed. Transarterial chemoembolization was the main modality of active treatment in all groups. In multivariate analysis, the performance score, model for end-stage liver disease score, modified Union for International Cancer Control staging, Barcelona Clinic Liver Cancer staging, presence of portal vein tumor thrombosis, ruptured HCC, and active treatment were risk factors of overall survival.
CONCLUSION:

When the therapeutic approach is used in elderly patients with HCC, the patient's performance status, liver function, and stage of cancer should be considered, and its use should not be restricted to those of advanced age.

Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
KEYWORDS:

Hepatocellular carcinoma; efficacy; extreme elderly; safety

PMID:
    30587615
DOI:
    10.21873/invivo.11451

StephenW

体内。 2019年1月至2月; 33（1）：145-154。 doi：10.21873 / invivo.11451。
韩国极端老年人肝细胞癌的特征和结局。
Seo JH1，Kim DH1，Cho E1，Jun CH2，Park SY1，Cho SB1，Park CH1，Kim HS1，Choi SK1，Rew JS1。
作者信息

1
    韩国光州全南大学医院和医学院内科，消化内科。
2
    韩国光州全南大学医院和医学院内科，消化内科[email protected]。

抽象
背景/目的：

被诊断患有肝细胞癌（HCC）的老年患者的数量一直在增加。但是，根据老年患者的年龄分层，没有适当的管理。因此，我们评估了韩国75岁以上老年HCC患者的临床特征和结果。
患者和方法：

招募了520名老年HCC患者，分为年龄最大（年龄≥85岁），中年（80-85岁）和年龄组（年龄75-80岁）。
结果：

51名，153名和346名患者分别包括在年龄最大的（平均年龄：87岁），中年（平均年龄：82岁）和年轻组（平均年龄：77岁）中。老年组中酒精相关和乙型肝炎病毒相关疾病的发生率显着低于其他组，而其他特征没有显着差异。随着年龄的增长，主要进行保守治疗。经动脉化疗栓塞是所有组中主动治疗的主要方式。在多变量分析中，性能评分，终末期肝病评分模型，改良联盟国际癌症控制分期，巴塞罗那临床肝癌分期，门静脉癌栓的存在，HCC破裂和积极治疗是总体生存的危险因素。
结论：

当治疗方法用于老年HCC患者时，应考虑患者的表现状态，肝功能和癌症分期，其使用不应局限于高龄患者。

版权所有©2019，国际抗癌研究所（George J. Delinasios博士），保留所有权利。
关键词：

肝细胞癌;功效;极端老人;安全

结论：
    30587615
DOI：
    10.21873 / invivo.11451

StephenW

http://iv.iiarjournals.org/content/33/1/145.long