老年肝细胞癌患者的肝切除术：对17,000多名患者进行了系统

StephenW

Hepatic resection for elderly patients with hepatocellular carcinoma: a systematic review of more than 17,000 patients
Ling-Yun Zhao, Rong-Rui Huo, Xiao Xiang, Guido Torzilli, Ming-Hua Zheng, Tian Yang, show all

                          Pages 1059-1068 | Received 06 Mar 2018, Accepted 24 Aug 2018, Accepted author version posted online: 26 Aug 2018, Published online: 05 Sep 2018
  

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•             https://doi.org/10.1080/17474124.2018.1517045
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                                                                                                                                                         ABSTRACT

Background: With the aging population and increasing incidence of hepatic malignancies in elderly patients, establishing the safety and efficacy of hepatic resection for elderly patients with hepatocellular carcinoma (HCC) is crucial. The present systematic review investigates postoperative morbidity, hospital mortality, median survival time, overall and disease-free survival in elderly patients with undergoing hepatic resection.
Methods: Some databases were systematically searched for prospective or retrospective studies to reveal the safety and efficacy of hepatic resection for elderly patients with primary HCC.
Results: Fifty studies involving 4,169 elderly patients and 13,158 young patients with HCC were included into analyses. Elderly group patients had similar rate of median postoperative morbidity (28.2% vs. 29.6%) but higher mortality (3.0% vs. 1.2%) with young group patients. Moreover, elderly group patients had slightly lower median survival time (55 vs. 58 months), 5-years overall survival (51% vs. 56%) and 5-years disease-free survival (27% vs. 28%) than young group patients. There was an upward trend in 5-years overall and disease-free survival in either elderly or young group.
Conclusion: Though old age may increase the risk of hospital mortality for patients with HCC after hepatic resection, elderly patients can obtain acceptable long-term prognoses from hepatic resection.


KEYWORDS: Elderly patients, hepatic resection, hepatocellular carcinoma, mortality, overall survival

StephenW

老年肝细胞癌患者的肝切除术：对17,000多名患者进行了系统评价
赵玲云，霍荣瑞，肖翔，Guido Torzilli，郑明华，田阳，全部展示
第1059-1068页| 2018年3月6日收到，2018年8月24日接受，接受作者版本在线发布：2018年8月26日，在线发布：2018年9月5日

    下载引文https://doi.org/10.1080/17474124.2018.1517045


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抽象

背景：随着人口老龄化和老年患者肝脏恶性肿瘤发病率的增加，确定老年肝细胞癌（HCC）肝切除术的安全性和有效性至关重要。本系统评价调查了老年肝切除术患者的术后发病率，住院死亡率，中位生存时间，总体和无病生存率。

方法：系统地搜索一些数据库进行前瞻性或回顾性研究，以揭示老年原发性肝癌患者肝切除术的安全性和有效性。

结果：包括4,169名老年患者和13,158名年轻HCC患者的50项研究纳入分析。老年组患者术后中位发病率中位数相似（28.2％对29.6％），但年轻组患者死亡率较高（3.0％对1.2％）。此外，老年组患者的中位生存时间（55对58个月），5年总生存率（51％对56％）和5年无病生存率（27％对28％）略低于年轻人小组患者。无论是老年人还是年轻人，总体上有5年的上升趋势和无病生存率。

结论：老年患者虽然老年可能增加肝切除术后HCC患者的住院死亡风险，但老年患者可以从肝切除术中获得可接受的长期预后。
关键词：老年患者，肝切除术，肝细胞癌，死亡率，总生存率