职业暴露之间的时间接受乙肝病毒和乙肝免疫球蛋白注射液

StephenW

Am J Infect Control. 2015 Oct 27. pii: S0196-6553(15)00941-4. doi: 10.1016/j.ajic.2015.08.024. [Epub ahead of print]
The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection: Results from a Korean nationwide, multicenter study.
Chang HH1, Lee WK1, Moon C2, Choi WS3, Yoon HJ4, Kim J5, Ryu SY6, Kim HA6, Jo YM7, Kwon KT8, Kim HI8, Sohn JW9, Yoon YK9, Jung SI10, Park KH10, Kwon HH11, Lee MS12, Kim YK13, Kim YS14, Hur J15, Kim SW16.
Author information

    1Kyungpook National University Hospital School of Medicine, Daegu, Korea.
    2Inje University Busan Paik Hospital, Busan, Korea.
    3Korea University Ansan Hospital College of Medicine, Seoul, Korea.
    4Eulji University Hospital, Daejeon, Korea.
    5Hanyang University Guri Hospital, Guri, Korea.
    6Keimyung University Dongsan Medical Center, Daegu, Korea.
    7Konyang University College of Medicine, Daejeon, Korea.
    8Daegu Fatima Hospital, Daegu, Korea.
    9Korea University College of Medicine, Seoul, Korea.
    10Chonnam National University Hospital Medical School, Gwangju, Korea.
    11Catholic University of Daegu School of Medicine, Daegu, Korea.
    12Kyung Hee University School of Medicine, Seoul, Korea.
    13Wonju Severance Christian Hospital, Wonju, Korea.
    14Chungnam National University School of Medicine, Daejeon, Korea.
    15Yeungnam University Medical Center, Daegu, Korea.
    16Kyungpook National University Hospital School of Medicine, Daegu, Korea. Electronic address: [email protected].

Abstract
BACKGROUND:

Postexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an important role in the prevention of HBV infections in health care workers (HCWs). We examined data concerning the acceptable duration between occupational exposure and administration of a hepatitis B immunoglobulin (HBIG) injection in an occupational clinical setting.
METHODS:

A retrospective analysis was conducted with data from 143 cases of HCWs exposed to HBV in 15 secondary and tertiary teaching hospitals between January 2005 and June 2013. Data were taken from the infection control records of each hospital.
RESULTS:

Active vaccination after HBV exposure was started in 119 cases (83.2%) and postvaccination testing for hepatitis B antibody showed positive seroconversion in 93% of cases. In 98 cases (68.5%), HBIG was administered within 24 hours after HBV exposure; however, 45 HCWs (31.5%) received an HBIG injection more than 24 hours postexposure and 2 among the 45 received an injection after 7 days. Although 31.5% received an HBIG injection more than 24 hours postexposure, no cases of seroconversion to hepatitis b antibody positivity occurred.
CONCLUSIONS:

For susceptible HCWs, HBIG administered between 24 hours and 7 days postexposure may be as effective as administration within 24 hours in preventing occupational HBV infection.

Copyright © 2015 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
KEYWORDS:

Health care workers; Hepatitis B virus; Occupational exposure; Postexposure prophylaxis; Treatment outcomes

PMID:
    26518500
    [PubMed - as supplied by publisher]

StephenW

牛J传染控制。 2015年27月PII：S0196-6553（15）00941-4。 DOI：10.1016 / j.ajic.2015.08.024。 [打印EPUB提前]
职业暴露之间的时间接受乙肝病毒和乙肝免疫球蛋白注射液：结果从韩国全国多中心临床研究。
昌HH1，李WK1，月亮C2，崔WS3，尹HJ4，金J5，刘某SY6，金HA6，乔YM7，权KT8，金HI8，孙某JW9，尹YK9，荣格SI10，公园KH10，权HH11，李MS12金YK13，金YS14，许J15，金SW16。
作者信息

    1Kyungpook国立大学医院医学院，韩国大邱的。
    2Inje大学釜山白医院，釜山，韩国。
    3Korea大学安山医院医学院，首尔，韩国。
    4Eulji大学医院，大田，韩国。
    5Hanyang大学九里医院，九里，韩国。
    6Keimyung大学东山医疗中心，韩国大邱。
    7Konyang大学医学院，韩国大田的。
    8Daegu法蒂玛医院，韩国大邱。
    9Korea大学医学院，韩国首尔。
    10Chonnam国立大学医院医学院，韩国光州。
    医药，大邱，韩国大邱学院11Catholic大学。
    12Kyung熙大学医学院，韩国首尔。
    13Wonju遣散基督教医院，原州，韩国。
    14Chungnam国立大学医学院，韩国大田的。
    15Yeungnam大学医学中心，韩国大邱。
    16Kyungpook国立大学医院医学院，韩国大邱的。电子地址：[email protected]。

抽象的
背景：

暴露后预防职业接触乙型肝炎病毒（HBV）在预防乙肝病毒感染的医护人员（医护人员）中的重要作用。我们研究关于职业临床上乙肝免疫球蛋白（HBIG）注射职业暴露和管理之间的可接受的持续时间数据。
方法：

回顾性分析与取自各医院的感染控制记录，从143案件2005年1月和2013年6月间的数据暴露于HBV在15个二，三级教学医院医务人员的数据进行的。
结果：

乙肝病毒暴露后疫苗接种活动启动119例（83.2％）和接种后的检测乙肝抗体呈阳性转阴病例的93％。在98例（68.5％），乙型肝炎免疫球蛋白是乙肝病毒暴露后24小时内给药;然而，45医护人员（31.5％）接受一个HBIG喷射时间超过24小时暴露后和2间的45接收到注射后7天。虽然31.5％收到HBIG喷射时间超过24小时的暴露后，没有发生血清转换到乙肝抗体阳性的发生。
结论：

对于敏感的医护人员，乙肝免疫球蛋白给予24小时，7天暴露后的可能是一样有效的管理在24小时内以预防职业HBV感染。

版权所有©2015年协会在感染控制及流行病学，公司专业出版由Elsevier公司保留所有权利。
关键词：

医护人员;乙型肝炎病毒;职业暴露;暴露后预防;治疗结果

结论：
    26518500
    [考研 - 由发行商提供]