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J Med Virol. 2013 Jan 7. doi: 10.1002/jmv.23500. [Epub ahead of print]
Comparative analysis of viral genomes from acute and chronic hepatitis B
reveals novel variants associated with a lower rate of chronicity.
急性和慢性B型肝炎病毒基因组的比较分析
揭示了新的
一个较低的长期性
变种。
Chook JB, Ngeow YF, Khang TF, Ng KP, Tiang YP, Mohamed R.
Source
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala
Lumpur, Malaysia.
Abstract
Infection with the hepatitis B virus (HBV) may lead to an acute or chronic
infection. It is generally accepted that the clinical outcome of infection
depends on the balance between host immunity and viral survival strategies.
In order to persist, the virus needs to have a high rate of replication
and some immune-escape capabilities. Hence, HBVs lacking these properties
are likely to be eliminated more rapidly by the host, leading to a lower
rate of chronicity. To test this hypothesis, 177 HBV genomes from acute
non-fulminant cases and 1,149 from chronic cases were retrieved from
GenBank for comparative analysis. Selection of candidate nucleotides
associated with the disease state was done using random guess cut-off and
the Bonferroni correction. Five significant nucleotides were detected using
this filtering step. Their predictive values were assessed using the
support vector machine classification with five-fold cross-validation. The
average prediction accuracy was 61% ± 1%, with a sensitivity of 24% ± 1%,
specificity of 98% ± 1%, positive predictive value of 92% ± 4% and
negative predictive value of 56% ± 1%. BCP/X, enhancer I and
surface/polymerase variants were found to be associated almost exclusively
with acute hepatitis. These HBV variants are novel potential markers for
non-progression to chronic hepatitis. J. Med. Virol. © 2013 Wiley
Periodicals, Inc. |
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发表于 2013-1-21 23:24