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本帖最后由 风雨不动 于 2012-4-14 15:09 编辑
Eur J Gastroenterol Hepatol. 2011 May 26. [Epub ahead of print]
Prevalence of hepatitis B in the southeast of China: a population-based
study with a large sample size.
Luo Z, Xie Y, Deng M, Zhou X, Ruan B.
Source
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,
The First Affiliated Hospital, College of Medicine, Zhejiang University,
Hangzhou, People's Republic of China.
Abstract
OBJECTIVE:
Hepatitis B is a major public health problem in China. However, in the past
10 years, estimates of the prevalence of hepatitis B virus (HBV) have been
sparse, with results that do not always agree. The purpose of this study
was to investigate the epidemiology of HBV in adults and to provide the
most recent baseline data for planning and monitoring of health.
METHODS:
The prevalence of HBV was determined in a community-based, cross-sectional,
age-stratified sample of adults (aged 20 years or older). The study
population was selected using random multistage cluster sampling.
Demographic information and serological samples were obtained from 19 933
participants.
RESULTS:
The prevalence of anti-HBV core antibody, HBV surface antigen (HBsAg), and
anti-HBV surface antibody was 38.6, 7.9, and 44.9%, respectively. We found
statistically significant differences in hepatitis B infection between men
and women (P<0.001). The prevalence of HBV infection increased with age.
The rates of HBsAg positivity and HBV infection in individuals living on an
island were higher than those of individuals living in plains. The alanine
aminotransferase level was elevated (กร38 IU/l) in 15.7 and 7.2% of
HBsAg-positive and HBsAg-negative patients; the proportion of elevated
alanine aminotransferase was markedly higher in men (12.7%) than in women
(4.7%) (P<0.001). The ฅแ-fetoprotein-positive rate was 2% in HBsAg-positive
individuals who were aged 30 years or older.
CONCLUSION:
Borderline intermediate/high endemicity was found among adults in the
northern region of Zhejiang Province. The vaccination program has
contributed to a reduction in infection over the last 20 years, although
further efforts are required to turn the region into a 'low-endemicity'
area.
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