The relationship between liver disease stage and liver fibrosis: a tangled web

StephenW

<http://www.ingentaconnect.com/content/bsc/histo/2010/00000057/00000006/art00001>


The relationship between liver disease stage and liver fibrosis: a tangled web

Authors: Germani, Giacomo1; Burroughs, Andrew K1; Dhillon, Amar P2

Source: Histopathology, Volume 57, Number 6, December 2010 , pp. 773-784(12)

Publisher: Wiley-Blackwell

Abstract:
Germani G, Burroughs A K & Dhillon A P
(2010) Histopathology57, 773-784

The relationship between liver disease stage and liver fibrosis: a tangled web
The structural consequences of chronic liver disease are described as a series
of liver disease `stages' with scarring and architectural change that eventually
destroys and replaces the normal lobular structure of the liver. Fibrosis
(`excess collagen') and stage have been confused in histological staging
systems. Fibrosis is part of increasing liver disease stage, but fibrosis and
stage are different. Staging liver disease is important in routine
histopathological assessment. Measurement of liver fibrosis is another process.
The collagenous proportion of a liver biopsy [collagen proportionate area (CPA)]
correlates with hepatic venous pressure gradient (HVPG), which is of recognized
prognostic value. CPA at 1 year post-transplantation in hepatitis C
virus-infected patients predicts subsequent clinical decompensation. CPA in
cirrhotic patients predicts decompensation more accurately than staging or HVPG.
The `cirrhosis' stage category has poor prognostic power, and CPA effectively
substages cirrhosis. CPA improves the description of liver disease stage. Proper
validation of antifibrotic treatments and `non-invasive markers of liver
fibrosis' requires measurement of liver fibrosis (and not liver biopsy stage
scores). It is unacceptable for the words `fibrosis' and `score' to remain next
to each other. There are benefits to properly understanding liver fibrosis and
liver disease stage and properly assessing each of them.

Document Type: Research article
DOI: 10.1111/j.1365-2559.2010.03609.x
Affiliations: 1: The Royal Free Sheila Sherlock Liver Centre and University
Department of Surgery UCL, Royal Free Hospital 2: Department of Cellular
Pathology, UCL Medical School, Royal Free Campus, London, UK Publication date:
2010-12-01

与肝疾病的阶段和肝纤维化的关系：一个复杂的网

作者：Germani，Giacomo1，宝来，安德鲁K1的; Dhillon，阿马尔的P2

来源：组织病理学，卷57，第6期，2010年12月，第773-784（12）

出版商：威利-布莱克韦尔

摘要：
Germani克，巴勒斯的K＆Dhillon一个P
（2010）Histopathology57，773-784

与肝疾病的阶段和肝纤维化的关系：一个复杂的网
慢性肝病的结构性后果被描述为一个系列
肝病`阶段，形成瘢痕和建筑的变化，最终'
破坏并取代正常的肝脏小叶结构。纤维化
（`过量胶原蛋白'）和阶段已组织举办混淆
系统。纤维化是肝脏疾病的一部分，越来越多的阶段，但纤维化
阶段是不同的。分期肝病是在例行重要
组织病理学评估。肝纤维化的测量是另一个进程。
一个肝活检胶原比例[胶原比例区（注册会计师）]
相关与肝静脉压力梯度（HVPG），这是公认的
预后价值。注册会计师在1年后移植的C型肝炎
病毒感染患者的临床预测随后的代偿。注册会计师
肝硬化失代偿患者更精确地预测分期或HVPG的。
肝硬化的`'的阶段分类预后不良的力量，有效地注册会计师
substages肝硬化。注册会计师提高了肝脏疾病阶段的描述。适当
抗肝纤维化治疗验证和`非侵入性肝标记
肝纤维化，肝纤维化要求（而不是测量肝活检阶段
分）。它是纤维化的话`'和'分数'不可接受留下一页
对方。有其好处，正确理解和肝纤维化
肝病阶段，适当地评估它们。

文件类型：研究论文
分类号：10.1111/j.1365-2559.2010.03609.x
背景：1：皇家自由希拉福尔摩斯肝脏中心和大学
伦敦大学外科部，皇家自由医院2：细胞系
病理学，伦敦大学医学院，英国皇家无烟校园，伦敦，英国出版日期：
2010年12月1日





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oceanseleven

Do you translate all the abstracts into Chinese yourself?

StephenW

回复 oceanseleven 的帖子

No, I just use Google Translate, which is less than perfect. Most of the posts are very technical and very difficult to translate. I am open to any reasonable suggestions.