乙肝基金会对乙肝儿童监控和治疗的建议

shouhu

乙肝多数是以前的不严谨医疗行为造成的！

aries10000

希望以后能出更好的药进行有效的治疗。

我随心动

update from the recent HEPDART 2011 conference

The efficiency of treatment with lamivudine in children with chronic B hepatitis and negative HBe antigen

ABSTRACT 93
The efficiency of treatment with
lamivudine in children with chronic B
hepatitis and negative HBe antigen
M Pop1, O Belei2, and I Simedrea2
1 Third Pediatric Clinic, Victor Babes University of
Medicine and Pharmacy Timisoara, Romania; 2 First
Pediatric Clinic, Victor Babes University of Medicine and
Pharmacy Timisoara, Romania
OBJECTIVE: Evaluation of response Lamivudine
treatment in children with chronic B hepatitis (CH–
HBV) with negative HBeAg.
METHODS: We studied 26 patients aged between
9–17 years with chronic B hepatitis, and negative
HBeAg, previously treated with Lamivudine 4 mg/
kg/day for about 24 months. In 14 cases Lamivudine
therapy was the second alternative of treatment,
because Interpheron α 2b was the first intention for
6 months, without results. All the patients have been
monitored clinically as well as liver function every
month, viral markers 2 times/ year (HBsAg, HBs-
Ab, HBeAg, HBe-Ab, DNA-HBV), immunologically 2
times/ year (CD3, CD4, CD8, immunoglobulines level).
The liver biopsy has been performed in all patients at
the beginning of treatment and after treatment in only
6 cases. We used the scor Knodell for necroinflamatory
activity appreciation.
RESULTS: Clinical symptoms of disease have gradually
improved in most of the cases. Aminotransferases
normalized in 90% of them. The hepatocytolytic
syndrome had improved so: for 60% after 3 months,
75% after 6 months and 90% after 12 months
of treatment. In only 1 case, we have noticed the
seroconversion from AgHBs to HBs-antibody. The
viral clearance (absence of DNA-HBV in serum) was
19,23 % after 12 months and 38,4% (10 cases) after 24
months of treatment. In 33,3% of the patients tested,
Knodell score decreased with 2 points.
CONCLUSIONS: Clinical symptomatology and
cytolytic liver syndrome and responded in a short
period of time during treatment. Serum clearance
of DNA–HBV was 19,23% (5 cases) after 12 months
and 38,4% (10 cases) after 24 months of treatment.
HBs-Ab seroconversion appeared in only one case. The compliance and tolerance for Lamivudine treatment
was very good.

ywzhanghw

谢谢版大