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Thiazolidinedione From Wikipedia, the free encyclopedia
Thiazolidinedione
From Wikipedia, the free encyclopedia
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The thiazolidinediones (pronounced /θaɪəˌzoʊlɨdiːnˈdaɪoʊn/), also known as glitazones, are a class of medications used in the treatment of diabetes mellitus type 2. They were introduced in the late 1990s.
Contents [hide]
1 Mode of action
2 Members of the class
3 Uses
4 Side effects and contraindications
5 Footnotes
[edit] Mode of action
Thiazolidinediones or TZDs act by binding to PPARs (peroxisome proliferator-activated receptors), a group of receptor molecules inside the cell nucleus, specifically PPARγ (gamma). The ligands for these receptors are free fatty acids (FFAs) and eicosanoids. When activated, the receptor migrates to the DNA, activating transcription of a number of specific genes.
Genes upregulated by PPARγ can be found in the main article on peroxisome proliferator-activated receptors.
By activating PPARγ:
Insulin resistance is decreased
Adipocyte differentiation is modified [1]
VEGF-induced angiogenesis is inhibited[2]
Leptin levels decrease (leading to an increased appetite)
Levels of certain interleukins (e.g. IL-6) fall
Adiponectin levels rise
TZDs also increase the synthesis of certain proteins involved in fat and glucose metabolism, which reduces levels of certain types of lipids. TZDs generally decrease triglycerides and increase high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Although the increase in LDL-C may be more focused on the larger LDL particles, which may be less atherogenic, the clinical significance of this is currently unkown. Circulating levels of free fatty acids are also reduced by TZDs.
[edit] Members of the class
The chemical structure of thiazolidinedioneChemically, the members of this class are derivatives of the parent compound thiazolidinedione, and include:
Rosiglitazone (Avandia)
Pioglitazone (Actos)
Troglitazone (Rezulin), which was withdrawn from the market due to an increased incidence of drug-induced hepatitis.
Experimental agents include MCC-555, a powerful antidiabetic agent, rivoglitazone, and the early non-marketed thiazolidinedione ciglitazone.
Replacing one oxygen atom in a thiazolidinedione with an atom of sulfur gives a rhodanine.
[edit] Uses
The only approved use of the thiazolidinediones is in diabetes mellitus type 2.
It is being investigated experimentally in polycystic ovary syndrome (PCOS), non-alcoholic steatohepatitis (NASH),[3] psoriasis,[4] autism,[5] ovarian hyperstimulation syndrome (by VEGF inhibition in granulosa cells)[6] and other conditions.[7]
Several forms of lipodystrophy cause insulin resistance, which has responded favorably to thiazolidinediones. There are some indications that thiazolidinediones provide some degree of the protection against initial stages of the breast carcinoma development.
[edit] Side effects and contraindications
The withdrawal of troglitazone has led to concerns of the other thiazolidinediones also increasing the incidence of hepatitis and potential liver failure, an approximately 1 in 20,000 individual occurrence with troglitazone. Because of this, the FDA recommends two to three month checks of liver enzymes for the first year of thiazolidinedione therapy to check for this rare but potentially catastrophic complication. To date, 2008, the newer thiazolidinediones, rosiglitazone and pioglitazone have been free of this problem.
The main side effect of all thiazolidinediones is water retention, leading to edema, generally a problem in less than 5% of individuals, but a big problem for some and potentially, with significant water retention, leading to a decompensation of potentially previously unrecognized heart failure. Therefore, thiazolidinediones should be prescribed with both caution and patient warnings about the potential for water retention/weight gain, especially in patients with decreased ventricular function (NYHA grade III or IV heart failure).
Though recent studies have shown there may be an increased risk of coronary heart disease and heart attacks with rosiglitazone[8] pioglitazone treatment, in contrast, has shown significant protection from both micro- and macro-vascular cardiovascular events and plaque progression[9][10][11].
[edit] Footnotes
^ Waki H, Yamauchi T, Kadowaki T (February 2010). "[Regulation of differentiation and hypertrophy of adipocytes and adipokine network by PPARgamma]" (in Japanese). Nippon Rinsho 68 (2): 210–6. PMID 20158086.
^ Panigrahy D, Singer S, Shen LQ, et al. (2002). "PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis". J. Clin. Invest. 110 (7): 923–32. doi:10.1172/JCI15634. PMID 12370270.
^ Belfort R, Harrison SA, Brown K, et al. (November 2006). "A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis". N. Engl. J. Med. 355 (22): 2297–307. doi:10.1056/NEJMoa060326. PMID 17135584. Clinical trial info
^ Krentz AJ, Friedmann PS (March 2006). "Type 2 diabetes, psoriasis and thiazolidinediones". Int. J. Clin. Pract. 60 (3): 362–3. doi:10.1111/j.1368-5031.2005.00765.x. PMID 16494655.
^ Boris et al. Effect of pioglitazone treatment on behavioral symptoms in autistic children, Journal of Neuroinflammation 2007,4:3 [1]
^ Shah DK, Menon KM, Cabrera LM, Vahratian A, Kavoussi SK, Lebovic DI (April 2010). "Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro". Fertil. Steril. 93 (6): 2042–7. doi:10.1016/j.fertnstert.2009.02.059. PMID 19342033.
^ Clinical Trials for Rosiglitazone - from ClinicalTrials.gov, a service of the U.S. National Institutes of Health
^ "Avandia to Carry Stronger Heart Failure Warning - Forbes.com". http://www.forbes.com/forbeslife ... /hscout607350.html. Retrieved 2007-08-15.
^ Charbonnel B, Dormandy J, Erdmann E, Massi-Benedetti M, Skene A (July 2004). "The prospective pioglitazone clinical trial in macrovascular events (PROactive): can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients". Diabetes Care 27 (7): 1647–53. doi:10.2337/diacare.27.7.1647. PMID 15220241. http://care.diabetesjournals.org/cgi/content/abstract/27/7/1647.
^ Mannucci E, Monami M, Lamanna C, Gensini GF, Marchionni N (May 2008). "Pioglitazone and cardiovascular risk. A comprehensive meta-analysis of randomized clinical trials". Diabetes Obes Metab 0 (12): 080526191604039. doi:10.1111/j.1463-1326.2008.00892.x. PMID 18505403.
^ Nissen SE, Nicholls SJ, Wolski K, et al. (April 2008). "Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial". JAMA 299 (13): 1561–73. doi:10.1001/jama.299.13.1561. PMID 18378631. http://jama.ama-assn.org/cgi/content/full/299/13/1561.
[hide]v • d • eOral anti-diabetic drugs and Insulin analogs (A10)
Insulin Sensitizers Biguanides Metformin# · Buformin‡ · Phenformin‡
TZDs (PPAR) Pioglitazone · Rivoglitazone† · Rosiglitazone · Troglitazone‡
Dual PPAR agonists Aleglitazar† · Muraglitazar§ · Tesaglitazar§
Secretagogues K+ ATP Sulfonylureas 1st generation: Acetohexamide · Carbutamide · Chlorpropamide · Gliclazide · Tolbutamide · Tolazamide
2nd generation: Glibenclamide (Glyburide)# · Glipizide · Gliquidone · Glyclopyramide
3rd generation: Glimepiride
Meglitinides/"glinides" Nateglinide · Repaglinide · Mitiglinide
GLP-1 analogs Exenatide · Liraglutide · Taspoglutide† · Albiglutide†
DPP-4 inhibitors Alogliptin† · Linagliptin† · Saxagliptin · Sitagliptin · Vildagliptin
Analogs/other insulins fast acting (Insulin lispro · Insulin aspart · Insulin glulisine) · Short acting (Regular insulin) · long acting (Insulin glargine · Insulin detemir) · Inhalable insulin (Exubera)‡ · NPH insulin
Other Alpha-glucosidase inhibitors Acarbose · Miglitol · Voglibose
Amylin analog Pramlintide
SGLT2 inhibitors Canagliflozin† · Dapagliflozin† · Remogliflozin† · Sergliflozin†
Other Benfluorex · Tolrestat‡
#WHO-EM. ‡Withdrawn from market. CLINICAL TRIALS: †Phase III. §Never to phase III
M: END
anat/phys/devp/horm/cell
noco(d)/cong/tumr, sysi/epon
proc, drug (A10/H1/H3/H5)
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