复旦熊思东教授今年的文章，TRIM22分子抑制乙肝病毒，请教

hatecccdna

之前有人在学术区转帖过国内的新闻稿，讲得不清楚。
我把原文找出来了，今年8月发表于hepatology，下面贴出原文摘要。
有些地方不是很明白。
文中说这个TRIM22分子抑制乙肝病毒的转录，是不是说对cccDNA还是没有直接清除的作用？如果仅能单纯抑制病毒的合成的话，目前的核苷类抗病毒药已经达到相同效果了。
历史上出现过任何能直接清除病毒的药物吗？


Tripartite Motif-Containing 22 Inhibits the Activity of Hepatitis B Virus Core Promoter, Which Is Dependent on Nuclear-Located RING Domain

Author(s): Gao B (Gao, Bo)1, Duan ZJ (Duan, Zhijian)1, Xu W (Xu, Wei)1, Xiong SD (Xiong, Sidong)1,2  
Source: HEPATOLOGY    Volume: 50    Issue: 2    Pages: 424-433    Published: AUG 2009   
Times Cited: 0     References: 33     Citation Map      
Abstract: Members of the tripartite motif (TRIM) family are a part of the innate immune system to counter intracellular pathogens. TRIM22 has been reported to possess antiretroviral activity. Here we report that TRIM22 is involved in antiviral immunity against hepatitis B virus (HBV). Our results showed. that TRIM22, being a strongly induced gene by interferons in human hepatoma HepG2 cells, could inhibit HBV gene expression and replication in a cell culture system as well as in a mouse model system. Importantly, it was found that TRIM22 could inhibit the activity of HBV core promoter (CP) in a dose-dependent manner. However, TRIM22 lacking the C terminal SPRY domain lost this activity. Further study showed that the SPRY domain deletion mutant was localized exclusively to the cytoplasm of HepG2 cells. In contrast, the wild-type TRIM22 was localized to the nucleus, as expected for a transcriptional suppressor. Interestingly, although RING domain mutants of TRIM22 were localized to the nucleus, they could not inhibit HBV CP activity, indicating that TRIM22-mediated anti-HBV activity was dependent on the nuclear-located RING domain. Conclusion: These findings suggest that TRIM22, which exhibits anti-HBV activity by acting as a transcriptional suppressor, may play an important role in the clearance of HBV. (HEPATOLOGY 2009;50:424-433.)



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hatecccdna

另外，比较好的一点是，如果干扰素治疗乙肝的机理真的是这个引发这个TRIM22分子，那么以后的干扰素治疗就不用如此舍近求远了。可以直接研发更有效引发TRIM22分子的药物或者直接包含TRIM22分子的药物。

特深沉

只是每年发现的数百个与肝脏有关的分子当中的一个。

happyli

这个分子激活据说可以治疗乙肝，有些人可以康复，有些人恶化，据说和这个分子有关，aids是另一个分子其关键作用，希望科研人员继续深入研究。

富贵数字

要升级了 或者要钱了 就发个文章出来 好要钱 ,
对那些人真的很无语~

deng245

楼主辛苦了！感觉是篇浮夸文章。