- 现金
- 22902 元
- 精华
- 16
- 帖子
- 13768
- 注册时间
- 2006-12-19
- 最后登录
- 2019-7-12
|
1楼
发表于 2007-8-14 05:29
Why Women Have Lower Liver Cancer Rates: Estrogen May Inhibit Liver Cancer
Researchers, reporting in the July 6, 2007 issue of Science, say estrogen may play a key role in suppressing liver cancer. This may explain why women have lower rates of liver cancer, despite long-term infection with HBV or the hepatitis C virus (HCV). Men have three to five times the rate of liver cancer (also called hepatocellular carcinoma or HHC) than women. Mice experience that same gender difference in HCC. Researchers treated male and female mice with diethylnitrosamine (DEN), a liver cancercausing compound, to determine what caused the higher cancer rate in males. They found that the estrogen in female mice decreased the level of liver inflammation and liver cell injury resulting from DEN exposure. By suppressing inflammation, estrogen may help prevent the injury and excessive cell proliferation that can lead to liver tumors. When researchers removed estrogen from female mice, their liver cancer rates were equal to that of male mice. “We propose that estrogen- mediated inhibition of serum interleukin-6 (which causes inflammation) production by Kupffer cells reduces liver cancer risk in females, and these findings may be used to prevent HCC in males,” the researchers wrote.
|
|