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本帖最后由 StephenW 于 2022-9-9 11:59 编辑
骆驼奶改善酒精性肝损伤小鼠模型的炎症机制
梁铭、布勒奇、郝世奇、日木图吉
科学报告第 11 卷，文章编号：22811 (2021) 引用本文
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在游牧地区的传统医学实践中，骆驼奶 (CM) 被认为可以保护肝脏。本研究的目的是研究 CM 对慢性酒精性肝病 (ALD) 引起的肝脏生化和多组学改变的影响。采用灌胃小鼠Lieber DeCarli + Gao binge模型（NIAAA模型）研究骆驼奶对小鼠肝组织的炎症机制。进行了小鼠粪便的肠道微生物群以及小鼠肝脏的转录组和蛋白质组学分析。血清和肝脏生化指标分析表明，骆驼奶不仅可以防止酒精引起的结肠功能障碍和脂质积累，还可以调节氧化应激和炎性细胞因子的产生，从而预防小鼠慢性 ALD。骆驼奶处理的小鼠肠道微生物群落与未处理的对照组比模型组更相似，表明在酒精灌胃前后摄入骆驼奶可有效预防和缓解慢性酒精中毒引起的肠道微生物紊乱在老鼠身上。此外，肝组织的转录组和蛋白质组分析结果表明，骆驼奶可以通过调节炎症因子和免疫系统破坏来改善小鼠酒精性肝损伤。这项研究提供了对骆驼奶可以开发为无副作用和抗肝损伤的潜在功能性食品的分子机制的见解。
Camel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model
Liang Ming, Bule Qi, Shiqi Hao & Rimutu Ji
Scientific Reports volume 11, Article number: 22811 (2021) Cite this article
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Abstract
Camel milk (CM) is considered to protect the liver in the practice of traditional medicine in nomadic areas. The purpose of the present study was to investigate the effects of CM on the hepatic biochemical and multiple omics alterations induced by chronic alcoholic liver disease (ALD). An intragastric gavage mice Lieber DeCarli + Gao binge model (NIAAA model) was employed to investigate the inflammatory mechanism of camel milk on the liver tissue of mice. A gut microbiota of the feces of mice and transcriptomic and proteomic analyses of the liver of mice were performed. Analysis of serum and liver biochemical indexes revealed that camel milk not only prevents alcohol-induced colonic dysfunction and lipid accumulation, but also regulates oxidative stress and inflammatory cytokine production to protect against chronic ALD in mouse. The gut microbial community of mice treated with camel milk was more similar to the untreated control group than to the model group, indicating that the intake of camel milk pre- and post-alcohol gavage effectively prevents and alleviates the intestinal microbial disorder caused by chronic alcoholism in mice. Furthermore, the results of the transcriptomic and proteomic analyses of the liver tissue showed that camel milk can improve alcoholic liver injury in mice by regulating inflammatory factors and immune system disruptions. This study provides insights into the molecular mechanism by which camel milk can be developed as a potential functional food with no side effects and against liver injury.
https://www.nature.com/articles/s41598-021-02357-1 |
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楼主: grate01
发表于 2022-9-9 11:18
