中国农村老年人的非酒精性脂肪肝、血清细胞因子和痴呆：

StephenW

中国农村老年人的非酒精性脂肪肝、血清细胞因子和痴呆：一项基于人群的研究
王永祥 1 2 3 , 李远景 4 , 刘可可 1 2 3 , 韩晓蕾 2 3 , 董毅 2 3 , 王晓杰 2 3 , 王明奇 2 3 , 林聪 1 2 3 , 张庆华 1 2 3 , 唐诗1 2 3 侯婷婷 1 2 3 刘翠翠 1 2 3 林松 1 2 3 韩晓娟 1 2 3 Davide L Vetrano 4 杜逸峰 1 2 3 邱承轩 2 4
隶属关系
隶属关系

    1
    【作者单位】： 山东第一医科大学附属山东省立医院神经内科;
    2
    山东大学山东省立医院神经内科，山东济南
    3
    山东省神经系统疾病临床研究中心，山东济南
    4
    衰老研究中心，NVS 系，卡罗林斯卡学院和斯德哥尔摩大学，瑞典斯德哥尔摩。

    PMID：35608965 DOI：10.1111/ene.15416

抽象的

背景：关于非酒精性脂肪性肝病 (NAFLD) 是否与痴呆相关以及血清促炎细胞因子在该关联中的作用知之甚少。我们旨在调查居住在农村的老年人中 NAFLD、血清细胞因子和痴呆症的相互关系。

方法：这项基于人群的横断面研究包括 2018 年 3 月至 9 月居住在农村社区并接受检查的 5,129 名参与者（年龄≥60 岁；61.79% 为女性）。NAFLD 是在没有乙型肝炎的情况下通过经腹超声检查定义的或过量饮酒。在子样本中测量了血清细胞因子 (n=1,686)。痴呆、阿尔茨海默病 (AD) 和血管性痴呆 (VaD) 的诊断遵循国际标准。使用逻辑回归和中介模型分析数据。

结果：在 5,129 名参与者中，455 人（8.87%）被检测为中度至重度 NAFLD，292 人（5.69%）被诊断为痴呆（188 人患有 AD，96 人患有 VaD）。对于全因痴呆，与中度至重度（与无至轻度）NAFLD 相关的多变量调整优势比 (OR) 为 2.22（95% 置信区间，1.41-3.49），1.88 (1.01-3.50) AD 和 VaD 为 2.62 (1.33-5.17)。在细胞因子子样本中，控制多个潜在混杂因素后，中度至重度 NAFLD 与较高水平的血清单核细胞趋化蛋白 1 (MCP-1)、白细胞介素 17A (IL-17A)、白细胞介素 6 (IL -6)、白细胞介素8 (IL-8)和肿瘤坏死因子-α (TNF-α) (P<0.05)。中介分析表明，IL-6 介导了 NAFLD 和 VaD 之间 12.56% 的关联。

结论：在农村居住的中国老年人中，中度至重度 NAFLD 与痴呆和 AD 相关，尤其是与 VaD 相关，其中与 VaD 的关联部分由血清炎性细胞因子介导。

关键词：痴呆；炎;非酒精性脂肪肝病（NAFLD）；基于人群的研究；血清细胞因子。

本文受版权保护。版权所有。

StephenW

Non-alcoholic fatty liver disease, serum cytokines, and dementia among rural-dwelling older adults in China: a population-based study
Yongxiang Wang  1   2   3 , Yuanjing Li  4 , Keke Liu  1   2   3 , Xiaolei Han  2   3 , Yi Dong  2   3 , Xiaojie Wang  2   3 , Mingqi Wang  2   3 , Lin Cong  1   2   3 , Qinghua Zhang  1   2   3 , Shi Tang  1   2   3 , Tingting Hou  1   2   3 , Cuicui Liu  1   2   3 , Lin Song  1   2   3 , Xiaojuan Han  1   2   3 , Davide L Vetrano  4 , Yifeng Du  1   2   3 , Chengxuan Qiu  2   4
Affiliations
Affiliations

    1
    Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China.
    2
    Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China.
    3
    Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, P.R. China.
    4
    Aging Research Center, Department of NVS, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

    PMID: 35608965 DOI: 10.1111/ene.15416

Abstract

Background: Little is known about whether non-alcoholic fatty liver disease (NAFLD) is associated with dementia as well as the role of serum pro-inflammatory cytokines in the association. We aimed to investigate the interrelationships of NAFLD, serum cytokines, and dementias among rural-dwelling older adults.

Methods: This population-based cross-sectional study included 5,129 participants (age ≥60 years; 61.79% women) who were living in rural communities and examined in March-September 2018. NAFLD was defined through transabdominal ultrasound examination in the absence of hepatitis B or excessive alcohol consumption. Serum cytokines were measured in a subsample (n=1,686). Dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were diagnosed following international criteria. Data were analyzed with logistic regression and mediation models.

Results: Of the 5,129 participants, 455 (8.87%) were detected with moderate-to-severe NAFLD and 292 (5.69%) were diagnosed with dementia (188 with AD and 96 with VaD). The multivariable-adjusted odds ratios (ORs) associated with moderate-to-severe (vs. no-to-mild) NAFLD were 2.22 (95% confidence interval, 1.41-3.49) for all-cause dementia, 1.88 (1.01-3.50) for AD, and 2.62 (1.33-5.17) for VaD. In the cytokine subsample, controlling for multiple potential confounders, moderate-to-severe NAFLD was significantly associated with higher levels of serum monocyte chemotactic protein-1 (MCP-1), interleukin-17A (IL-17A), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) (P<0.05). The mediation analysis showed that IL-6 mediated 12.56% of the association between NAFLD and VaD.

Conclusions: Moderate-to-severe NAFLD is associated with dementia and AD, especially with VaD, among rural-dwelling Chinese older adults, in which the association with VaD is partly mediated by serum inflammatory cytokines.

Keywords: dementia; inflammation; non-alcoholic fatty liver disease (NAFLD); population-based study; serum cytokines.

This article is protected by copyright. All rights reserved.