TLR2，作为病原体识别受体，在乙型肝炎结果中起关键作用

StephenW

TLR2，作为病原体识别受体，在乙型肝炎结果中起关键作用

玛丽亚姆·纳吉布
, 阿什拉夫·卡里米尼克
和穆罕默德·卡泽米·阿拉巴巴迪
在线发布：2022年1月11日https://doi.org/10.1089/vim.2021.0141

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抽象的

活动性和非活动性慢性乙型肝炎的免疫系统，作为乙型肝炎的延长形式，无法从受感染的肝细胞中完全根除乙型肝炎病毒 (HBV)。 Toll 样受体 (TLR) 在病毒识别和促进适当的免疫反应中起关键作用。这些分子还参与靶细胞功能的改变和转化。 TLR2 是一种独特的分子，可与 TLR1 和 6 形成同源二聚体或异源二聚体，并显示出不同的抗病毒感染作用。因此，假设 TLR2 可能参与针对 HBV 的免疫反应和病毒相关肝脏并发症的诱导。研究证实了这一假设，并揭示 TLR2 不仅是改变 HBV 感染过程的主要分子之一，而且在肝细胞癌 (HCC) 和肝硬化的诱导中起关键作用。然而，最近的研究表明，该分子可以对抗 HCC 和肝硬化。总的来说，营养习惯、TLR2 基因多态性、肠道微生物组、HBV 抗原和其他受体的激活可能在 TLR2 功能的确定中起关键作用。

StephenW

TLR2, as a Pathogen Recognition Receptor, Plays Critical Roles in Hepatitis B Outcome

Maryam Naghib
, Ashraf Kariminik
, and Mohammad Kazemi Arababadi
Published Online:11 Jan 2022https://doi.org/10.1089/vim.2021.0141

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Abstract

The immune system of active and inactive chronic hepatitis B, as prolonged forms of hepatitis B, is unable to eradicate hepatitis B virus (HBV) from the infected hepatocytes completely. Toll-like receptors (TLRs) play key roles in the viral recognition and promotion of appropriate immune responses. The molecules also participate in the alteration of the target cell functions and transformation. TLR2 is the unique molecule that makes either homodimer or heterodimer with TLR1 and 6 and shows variable roles against viral infections. Therefore, it has been hypothesized that TLR2 may participate in both immune response against HBV and induction of the virus-related hepatic complications. The studies confirm the hypothesis and revealed that TLR2 is not only one of the main molecules altering the course of HBV infection, but also plays key roles in induction of hepatocellular carcinoma (HCC) and liver cirrhosis. However, recent studies demonstrated that the molecule can fight against HCC and liver cirrhosis. Collectively, it appears that nutrition habits, TLR2 gene polymorphisms, gut microbiome, HBV antigens, and activation of other receptors may play key roles in the determination of TLR2 functions.

StephenW

https://www.liebertpub.com/doi/1 ... +January+26%2C+2022