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http://pdfs.semanticscholar.org/ ... 20d7b9131ac6a75.pdf
Predictive factors for spontaneous HBsAg seroclearance
Predictive factors of HBsAg seroclearance
Host factors
•Older age [4,6,8–10,12,13,15,17,20]
• Gender: female>male [8], male>female [6]• Normal alanine aminotransferease levels at baseline [4,15]
• Inactive carrier state>reactivation of hepatitis B [6]• Fatty liver [27,28]
• Cirrhosis at baseline [17] or development during follow-up [4]Viral factors
自发性HBsAg血清清除的预测因素
HBsAg血清清除率的预测因素
寄主因素
•年龄较大[4,6,8–10,12,13,15,17,20]
•性别:女性>男性[8],男性>女性[6]•基线时丙氨酸氨基转移酶水平正常[4,15]
•无效的携带者状态>乙型肝炎的再激活[6]•脂肪肝[27,28]
•基线时肝硬化[17]或随访中发展[4]病毒因素
•基线时HBeAg阴性[4,12,15]•基线时通过杂交乙型肝炎病毒DNA阴性[15]
•基因型:B> C [31],A> D [17]•丙型肝炎病毒重复感染[20,38]
病毒因素
•基线时HBeAg阴性[4,12,15]
•通过基线杂交获得的乙型肝炎病毒DNA阴性[15]
•基因型:B> C [31],A> D [17]
•丙型肝炎病毒重叠感染[20,38]
• HBeAg negativity at baseline [4,12,15]• Hepatitis B virus DNA negativity by hybridization at baseline [15]
• Genotype: B>C [31], A>D [17]• Hepatitis C virus superinfection [20,38]
Viral factors
• HBeAg negativity at baseline [4,12,15]
• Hepatitis B virus DNA negativity by hybridization at baseline [15]
• Genotype: B>C [31], A>D [17]
• Hepatitis C virus superinfection [20,38] |
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