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标题: 香港市民对乙型肝炎病毒感染情况的认识 [打印本页]

作者: StephenW 时间: 2021-2-11 19:47 标题: 香港市民对乙型肝炎病毒感染情况的认识

Awareness of hepatitis B virus infection status in the general population in Hong Kong

N.S. Wong
S.S. Lee
C.M. Poon
D.P.C. Chan
C.P. Chan

Open AccessDOI:https://doi.org/10.1016/j.ijid.2020.09.1233

Article Info

Background: Awareness of one's hepatitis B virus (HBV) infection status is the pre-requisite for achieving its elimination in the population, a 2030 target set by WHO. This study aims to determine the level of awareness of HBV infection status in the general population in Hong Kong.
Methods and materials: In this territory-wide seroprevalence study, households were invited through spatial random selection of residential address by building groups in Hong Kong. Blood samples, completed consent form and questionnaires were collected from participating household members. Information on socio-demographics, risk exposure to hepatitis virus, HBV vaccination history and known disease statuses were collected. Three HBV markers – HBsAg, anti-HBs and anti-HBc were tested. Lack of awareness of infection status was defined by inconsistency between self-reported status and laboratory test results. Factors associated with lack of awareness were explored in logistic regression.
Results: Between October 2018 and August 2019, 489 individuals from 273 households were recruited. Of 489 participants, the mean age was 51 year-old (SD = 16 year-old), 207 (42%) were male, 478 (98%) were local residents, 207 (42%) had attained post-secondary education level, and 274 (56%) were economically active. Among 480 blood samples, 39 (8%) were tested HBsAg +ve/anti-HBs −ve, 230 (48%) HBsAg −ve/anti-HBs +ve, 169 (35%) negative for HBsAg, anti-HBs and anti-HBc, and 42 (9%) were anti-HBc positive only. Among current HBsAg-positive participants (n = 39), 26 (67%) were aware of their infection status. Overall, 330 (67%) reported that they did not know their HBV infection status, and 338 (69%) participants’ self-reported status was not consistent with testing results. Factors associated with lack of awareness included male gender (OR = 1.55), lower education level (OR = 1.94), being economically inactive (OR = 1.93), absence of liver diseases (OR = 1.79), no family members diagnosed with hepatitis B (OR = 1.76), and absence of a hepatitis B vaccination history (OR = 4.04).
Conclusion: Low awareness of one's HBV infection status is not uncommon in the general population in Hong Kong. This could be an obstacle for implementing interventions for achieving HBV elimination. Population level HBV screening could move the step forward.
Article Info
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DOI: https://doi.org/10.1016/j.ijid.2020.09.1233
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作者: StephenW 时间: 2021-2-11 19:47

香港市民对乙型肝炎病毒感染情况的认识

N.S.王
李
厘米。胡桐
D.P.C.陈
C.P.陈

开放访问DOI：https：//doi.org/10.1016/j.ijid.2020.09.1233

文章信息

背景：认识到乙型肝炎病毒（HBV）感染状况是在人群中实现消灭乙肝病毒的先决条件，这是世界卫生组织设定的2030年目标。本研究旨在确定香港普通人群对乙肝病毒感染状况的认识水平。
方法和材料：在这项全香港的血清流行率研究中，香港的建筑群邀请住户通过空间随机选择居住地来进行邀请。从参与调查的家庭成员那里收集了血液样本，完整的同意书和问卷。收集了有关社会人口统计学，暴露于肝炎病毒的风险，HBV疫苗接种史和已知疾病状况的信息。测试了三种HBV标记-HBsAg，抗HBs和抗HBc。自我报告状态与实验室检测结果之间的不一致定义了对感染状态缺乏了解。在逻辑回归中探索了与缺乏认识相关的因素。
结果：2018年10月至2019年8月，共招募了273户家庭的489个人。在489名参与者中，平均年龄为51岁（SD = 16岁），男性207（42％），本地居民478（98％），达到专上教育水平的207（42％），其中274（56％）人经济活跃。在480个血液样本中，有39（8％）被检测为HBsAg + ve /抗HBs -ve，230（48％）HBsAg -ve /抗HBs + ve，169（35％）HBsAg，抗-HBs阴性抗HBc，只有42例（9％）呈抗HBc阳性。在目前的HBsAg阳性参与者中（n = 39），有26名（67％）知道他们的感染状况。总体而言，有330名（67％）报告他们不知道自己的HBV感染状况，而338名（69％）参与者的自我报告状况与测试结果不一致。缺乏认识的相关因素包括男性（OR = 1.55），文化程度较低（OR = 1.94），缺乏经济活动（OR = 1.93），没有肝病（OR = 1.79），没有被诊断患有乙肝的家庭成员（OR ＝ 1.76），并且没有乙肝疫苗接种史（OR ＝ 4.04）。
结论：在香港普通人群中，人们对乙肝病毒感染状况的意识低下并不罕见。这可能是实施干预措施以消除HBV的障碍。人群HBV筛查可以向前迈进。
文章信息
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DOI：https：//doi.org/10.1016/j.ijid.2020.09.1233
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