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肝胆相照论坛 论坛 学术讨论& HBV English 维生素D肝病协会:生物学基础和作用机理 ...
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维生素D肝病协会:生物学基础和作用机理

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才高八斗

发表于 2021-1-16 13:35 |显示全部帖子
Vitamin D ‐ liver disease association: Biological basis and mechanisms of action
Christos Triantos
Ioanna Aggeletopoulou
Konstantinos Thomopoulos
Athanasia Mouzaki
First published: 06 January 2021
https://doi.org/10.1002/hep.31699

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1002/hep.31699
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Abstract

Vitamin D plays a major role in hepatic pathophysiology, demonstrated by studies showing that it actively inhibits liver fibrosis and that its deficiency is associated with liver dysfunction and severity of liver diseases. Vitamin D and its receptor (VDR) are involved in the regulation of innate and adaptive immune responses and emerging evidence suggests that they contribute to liver homeostasis by exerting antiproliferative, anti‐inflammatory and antifibrotic activities. Over the last decades, extensive research has been focused on the identification of the biochemical and molecular pathways that mediate vitamin D‐VDR cellular and genomic actions through which vitamin D regulates the expression of target genes and modulates the progression of liver diseases. In this review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D‐VDR signaling and how genetic variants influence inflammatory responses and fibrogenic outcomes. The delineation of the biological basis of the association between vitamin D and liver disease progression is important for the development of novel treatment strategies for liver diseases.

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才高八斗

发表于 2021-1-16 13:36 |显示全部帖子
维生素D肝病协会:生物学基础和作用机理
克里斯托斯·特兰托斯
约安娜·阿格莱托波洛
康斯坦丁诺斯(Konstantinos Thomopoulos)
阿萨纳西娅·穆扎基(Athanasia Mouzaki)
首次发布:2021年1月6日
https://doi.org/10.1002/hep.31699

本文已被接受发表,并且经过了完整的同行评审,但尚未经过复制编辑,排版,分页和校对过程,因此可能会导致此版本与“记录版本”之间的差异。请引用本文作为doi:10.1002 / hep.31699
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维生素D在肝病理生理中起着重要作用,研究表明,维生素D可以积极抑制肝纤维化,其缺乏与肝功能障碍和肝病严重程度有关。维生素D及其受体(VDR)参与先天性和适应性免疫反应的调节,并且新兴证据表明它们通过发挥抗增殖,抗炎和抗纤维化活性来促进肝脏稳态。在过去的几十年中,广泛的研究集中在介导维生素D-VDR细胞和基因组作用的生化和分子途径的识别上,维生素D通过这些途径调节靶基因的表达并调节肝病的进展。在这篇综述中,我们讨论了对维生素D-VDR信号传导涉及的分子机制以及遗传变异如何影响炎症反应和纤维化结果的最新进展。维生素D与肝病进展之间关联的生物学基础的描述对于开发新的肝病治疗策略非常重要。

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发表于 2021-1-16 16:43 |显示全部帖子
维生素d太重要了,但是没有明确的标准,比如要达到预防癌症需要维持什么水平

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发表于 2021-1-17 07:59 |显示全部帖子
似乎只有晒太阳获得的VD才有用,吃补充剂药丸不起作用
新药多起来!
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