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肝胆相照论坛 论坛 其他肝脏问题 “雙重打擊”聚乙二醇化干擾素-α成功治療了乙型肝炎和 ...
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“雙重打擊”聚乙二醇化干擾素-α成功治療了乙型肝炎和丁

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发表于 2020-12-22 11:16 |显示全部帖子
'Double-hit' pegylated interferon-alpha successfully treats Hepatitis B and Hepatitis D co-infection
Meha Bhuva  1 , Marie Moore  1 , Sambit Sen  1
Affiliations
Affiliation

    1
    Hepatology Department, Luton and Dunstable University Hospital, Luton, UK.

    PMID: 33343908 PMCID: PMC7733525 DOI: 10.1093/omcr/omaa084

Abstract

Hepatitis delta (HDV) infection is either acquired simultaneously with, or as a superinfection to, existing Hepatitis B (HBV). It leads to a serious form of chronic viral hepatitis and accelerated liver-related morbidity and mortality including hepatocellular carcinoma. Current treatment regimes propose Pegylated interferon-alpha for 48 weeks however sustained virological response (SVR) rates remain low. We report a patient who initially responded to Pegylated interferon treatment for HBV-HDV co-infection. Although initial improvement in viraemia from both virsues was seen, SVR was not achieved with ongoing progression of liver injury biochemically. However, the summative effect of a second course of Pegylated interferon 2 years later led to HDV cure (SVR 12 months post-treatment), very low level HBV carrier status (with persistently undetectable viral load) and ongoing biochemical normalization. This case illustrates a successful treatment strategy for persistent HBV-HDV co-infection where proposed treatment regimes elicit an initial response but SVR is not achieved.

© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected].

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发表于 2020-12-22 11:17 |显示全部帖子
“雙重打擊”聚乙二醇化干擾素-α成功治療了乙型肝炎和丁型肝炎的合併感染
Meha Bhuva 1,Marie Moore 1,Sambit Sen 1
隸屬關係
聯繫

    1個
    英國盧頓盧頓和鄧斯特布爾大學醫院肝病科。

    PMID:33343908 PMCID:PMC7733525 DOI:10.1093 / omcr / omaa084

抽象

乙型肝炎(HDV)感染可與現有的乙型肝炎(HBV)同時感染或作為其超級感染。它導致嚴重形式的慢性病毒性肝炎,並加速包括肝細胞癌在內的與肝臟相關的發病率和死亡率。目前的治療方案建議使用聚乙二醇化干擾素-α治療48週,但是持續的病毒學應答(SVR)率仍然很低。我們報導了最初對聚乙二醇化干擾素治療HBV-HDV合併感染有反應的患者。儘管可以看到兩種病毒引起的病毒血症都得到了初步改善,但隨著生化過程中肝臟損傷的不斷進展,仍未達到SVR。然而,兩年後第二療程的聚乙二醇化干擾素的累加作用導致HDV治愈(治療後12個月SVR),極低水平的HBV攜帶者狀態(持續檢測不到病毒載量)和持續的生化正常化。該病例說明了持續性HBV-HDV合併感染的成功治療策略,其中建議的治療方案可引起初始反應,但未實現SVR。

©2020作者。牛津大學出版社出版。版權所有。有關權限,請發送電子郵件至:[email protected]

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