A Bioinformatics Investigation Into Molecular Mechanism of Yinzhihuang Granules for Treating Hepatitis B by Network Pharmacology and Molecular Docking Verification
Jingyuan Zhang 1 , Xinkui Liu 1 , Wei Zhou 1 , Guoliang Cheng 2 , Jiarui Wu 3 , Siyu Guo 1 , Shanshan Jia 1 , Yingying Liu 1 , Bingbing Li 2 , Xiaomeng Zhang 1 , Miaomiao Wang 1
Affiliations
Affiliations
1
Beijing University of Chinese Medicine, Beijing, 100102, China.
2
State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, 276000, China.
3
Beijing University of Chinese Medicine, Beijing, 100102, China. [email protected].
PMID: 32651427 DOI: 10.1038/s41598-020-68224-7
Abstract
Yinzhihuang granules (YZHG) is a patented Chinese medicine for the treatment of hepatitis B. This study aimed to investigate the intrinsic mechanisms of YZHG in the treatment of hepatitis B and to provide new evidence and insights for its clinical application. The chemical compounds of YZHG were searched in the CNKI and PUBMED databases, and their putative targets were then predicted through a search of the SuperPred and Swiss Target Prediction databases. In addition, the targets of hepatitis B were obtained from TTD, PharmGKB and DisGeNET. The abovementioned data were visualized using Cytoscape 3.7.1, and network construction identified a total of 13 potential targets of YZHG in the treatment of hepatitis B. Molecular docking verification showed that CDK6, CDK2, TP53 and BRCA1 might be strongly correlated with hepatitis B treatment. Furthermore, GO and KEGG analyses indicated that the treatment of hepatitis B by YZHG might be related to positive regulation of transcription, positive regulation of gene expression, the hepatitis B pathway and the viral carcinogenesis pathway. Network pharmacology intuitively shows the multicomponent, multitarget and multichannel pharmacological effects of YZHG in the treatment of hepatitis B and provides a scientific basis for its mechanism of action. 作者: StephenW 时间: 2020-7-12 15:40