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肝胆相照论坛 论坛 学术讨论& HBV English 氧化应激相关基因多态性与中国北方汉族人群的乙型肝炎病 ...
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氧化应激相关基因多态性与中国北方汉族人群的乙型肝炎病

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62111 元 
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才高八斗

发表于 2020-1-24 21:28 |显示全部帖子
Front Genet. 2020 Jan 8;10:1290. doi: 10.3389/fgene.2019.01290. eCollection 2019.
Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population.
Ma N1, Liu W1, Zhang X1, Gao X1, Yu F2, Guo W1, Meng Y3, Gao P4, Zhou J4, Yuan M4, Mi Y4, Zhang L4, Qi S4, Li L4, Wang L1, Su Q5, Yang L1, Liu D1.
Author information

1
    Hebei Key Laboratory of Environment and Human Health, Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, China.
2
    The Hebei Key Laboratory of Gastroenterology, Division of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
3
    Antenatal Diagnosis Center, The Fourth Hospital of Shijiazhuang, Shijiazhuang, China.
4
    Hebei Key Laboratory of Environment and Human Health, Department of Social Medicine and Health Care Management, School of Public Health, Hebei Medical University, Shijiazhuang, China.
5
    School of Basic Medicine, Hebei Medical University, Shijiazhuang, China.

Abstract

Oxidative stress is closely related to the occurrence and development of various diseases such as cancer, diabetes, and cardiovascular and infectious diseases. We identified six critical genetic variants related to oxidative stress, and evaluated their main effects and their interaction effects on hepatitis B virus (HBV)-induced liver diseases. We enrolled 3,128 Han Chinese subjects into five groups: healthy controls, chronic hepatitis B (CHB), liver cirrhosis (LC), hepatocellular carcinoma (HCC), and natural clearance. We then determined the genotypes in each group for CYBA-rs4673, NCF4-rs1883112, NOX4-rs1836882, rs3017887, SOD2-rs4880, and GCLM-rs41303970, and evaluated the association between these variants and HBV-induced liver diseases. Gene-gene interactions were evaluated using generalized multifactor dimensionality reduction, logistic regression, and four-by-two tables. Significant associations were observed between healthy controls and the CIB group (CHB+LC+HCC). The CYBA-rs4673AG genotype was associated with a 1.356 rate of susceptibility of HBV-induced liver disease compared to the wild type GG genotype. The NCF4-rs1883112G allele occurred more frequently in healthy controls than in the CIB group in all three models (dominant, codominant, and recessive). Nox4-rs1836882 TC showed a protective association, being more frequent in healthy controls compared to the wild type TT genotype. GCLM-rs41303970A was associated with HBV-induced liver disease. The overall best model by multifactor dimensionality reduction was a five factor interaction model that had the highest cross validation consistency (10/10) and test accuracy (0.5669), P = 0.001. Oxidative stress-related gene polymorphisms are likely to be associated with HBV-induced liver disease, suggesting that information on these variations is useful for risk assessment of HBV-induced liver disease.

Copyright © 2020 Ma, Liu, Zhang, Gao, Yu, Guo, Meng, Gao, Zhou, Yuan, Mi, Zhang, Qi, Li, Wang, Su, Yang and Liu.
KEYWORDS:

CYBA; GCLM; NCF4; Nox4; gene polymorphisms; hepatitis B virus; oxidative stress

PMID:
    31969899
PMCID:
    PMC6960262
DOI:
    10.3389/fgene.2019.01290

Rank: 8Rank: 8

现金
62111 元 
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26 
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30441 
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2009-10-5 
最后登录
2022-12-28 

才高八斗

发表于 2020-1-24 21:29 |显示全部帖子
前卫2020年1月8日; 10:1290. Doi:10.3389 / fgene.2019.01290.eCollection 2019。
氧化应激相关基因多态性与中国北方汉族人群的乙型肝炎病毒引起的肝病相关。
马N1,刘W1,张X1,高X1,于F2,郭W1,孟Y3,高P4,周J4,袁M4,弥Y4,张L4,齐S4,李L4,王L1,苏Q5,杨L1 ,刘D1。
作者信息

1个
河北医科大学公共卫生学院流行病学与统计系河北省环境与人类健康重点实验室,石家庄
2
河北医科大学第二医院消化科,河北省肠胃病重点实验室,石家庄
3
石家庄市第四医院产前诊断中心。
4
河北医科大学公共卫生学院社会医学与卫生保健管理系河北省环境与人类健康重点实验室,石家庄
5
河北医科大学基础医学院,石家庄

抽象

氧化应激与各种疾病的发生和发展密切相关,例如癌症,糖尿病,心血管疾病和感染性疾病。我们鉴定了与氧化应激有关的六个关键遗传变异,并评估了它们对乙型肝炎病毒(HBV)引起的肝病的主要作用及其相互作用。我们将3128名汉族受试者分为五组:健康对照组,慢性乙型肝炎(CHB),肝硬化(LC),肝细胞癌(HCC)和自然清除率。然后,我们确定了各组中CYBA-rs4673,NCF4-rs1883112,NOX4-rs1836882,rs3017887,SOD2-rs4880和GCLM-rs41303970的基因型,并评估了这些变体与HBV诱导的肝病之间的关联。使用广义多因素降维,逻辑回归和四乘二表评估基因-基因相互作用。在健康对照组和CIB组之间(CHB + LC + HCC)观察到显着关联。与野生型GG基因型相比,CYBA-rs46 73AG基因型与HBV诱发的肝病易感性比率为1.356。在所有三个模型(显性,共性和隐性)中,健康对照组中的NCF4-rs1883112G等位基因发生率均高于CIB组。 Nox4-rs1836882 TC显示出保护性关联,与野生型TT基因型相比,在健康对照组中更为常见。 GCLM-rs41303970A与HBV诱发的肝病相关。通过多因素降维获得的总体最佳模型是五因素相互作用模型,该模型具有最高的交叉验证一致性(10/10)和测试准确性(0.5669),P = 0.001。氧化应激相关基因多态性可能与HBV诱发的肝病相关,这表明这些变异的信息对于HBV诱发的肝病的风险评估很有用。

版权所有©2020马,刘,张,高,于,郭,孟,高,周,元,密,张,齐,李,王,苏,杨,刘。
关键字:

赛巴GCLM; NCF4; Nox4;基因多态性乙型肝炎病毒;氧化应激

PMID:
31969899
PMCID:
PMC6960262
DOI:
10.3389 / fgene.2019.01290

Rank: 8Rank: 8

现金
62111 元 
精华
26 
帖子
30441 
注册时间
2009-10-5 
最后登录
2022-12-28 

才高八斗

发表于 2020-1-24 21:30 |显示全部帖子
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