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慢性D型肝炎的管理更新

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发表于 2019-10-23 17:48 |显示全部帖子

An update on the management of chronic hepatitis D
Pir Ahmad Shah, Saad Choudhry, Karen J Campoverde Reyes, Daryl T Y Lau
Gastroenterology Report, goz052, https://doi.org/10.1093/gastro/goz052
Published:
19 October 2019


Abstract

Hepatitis D virus (HDV) infection is associated with severe liver-related morbidity and mortality. The prevalence of HDV is rising especially among people who abuse drugs and immigrants from endemic areas. Reliable diagnostic assays with enhanced sensitivity and specificity are essential for screening at-risk populations. Until recently, interferon has been the only treatment for hepatitis D. Its efficacy is, however, limited and it is associated with significant side effects. A number of novel antiviral agents that target various stages of the HDV life cycle show promising results. They are currently in different phases of clinical development. This review focuses on the changing epidemiology, novel therapeutic agents, and updated management of chronic hepatitis delta.

Rank: 8Rank: 8

现金
62111 元 
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26 
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30441 
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2009-10-5 
最后登录
2022-12-28 

才高八斗

发表于 2019-10-23 17:49 |显示全部帖子
慢性D型肝炎的管理更新
Pir Ahmad Shah,Saad Choudhry,Karen J Campoverde Reyes,Daryl T Y Lau
胃肠病学报告,goz052,https://doi.org/10.1093/gastro/goz052
发布时间:
2019年10月19日


抽象

丁型肝炎病毒(HDV)感染与严重的肝脏相关发病率和死亡率有关。 HDV的流行率正在上升,尤其是在滥用毒品的人和来自流行地区的移民中。可靠的诊断方法具有增强的灵敏度和特异性,对于筛查高危人群至关重要。直到最近,干扰素仍是治疗D型肝炎的唯一方法。但是,其疗效有限,并且具有明显的副作用。针对HDV生命周期各个阶段的许多新型抗病毒药显示出令人鼓舞的结果。他们目前处于临床开发的不同阶段。这篇综述着重于流行病学的变化,新型治疗剂和慢性肝炎三角洲的更新管理。

Rank: 8Rank: 8

现金
62111 元 
精华
26 
帖子
30441 
注册时间
2009-10-5 
最后登录
2022-12-28 

才高八斗

发表于 2019-10-23 17:49 |显示全部帖子

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