Delta病毒共染治疗由乙型肝炎引起的慢性肝炎

StephenW

Int J Antimicrob Agents. 2019 Sep 18. pii: S0924-8579(19)30255-9. doi: 10.1016/j.ijantimicag.2019.09.012. [Epub ahead of print]
Treatment of chronic hepatitis due to Hepatitis B with Delta virus coinfection.
Brancaccio G1, Gaeta GB2.
Author information

1
    Infectious Diseases, Department of Molecular Medicine, University of Padua, Italy.
2
    Infectious Diseases, Department of Mental and Physical Health, Campania University, Naples, Italy. Electronic address: [email protected].

Abstract

Therapy of chronic hepatitis Delta virus infection remains an unmet need. An estimate 20-40 million individuals are infected worldwide, mostly with rapidly evolving liver disease. To date, only IFN-based therapy is recommended for hepatitis Delta; response rates are unsatisfactory and, in addition, many patients are intolerant or ineligible to IFN. In recent years innovative approachs have been in development, which targets virus entry into hepatocytes; inhibition of the host enzyme farnesyltransferase, which leads to inhibition of complete virion formation and release; blockade of HBsAg secretion, which inhibits virus release; IFN Lamda, which causes fewer adverse effects than IFN alfa. Clinical trials are ongoing with encouraging preliminary results.

Copyright © 2019. Published by Elsevier B.V.
KEYWORDS:

HBsAg release blockers: IFN Lambda; entry inhibitors; hepatitis B; hepatitis Delta; peg-IFN; prenylation inhibitors

PMID:
    31541699
DOI:
    10.1016/j.ijantimicag.2019.09.012

StephenW

Int J抗微生物剂。 2019年9月18日.pii：S0924-8579（19）30255-9。 doi：10.1016 / j.ijantimicag.2019.09.012。 [Epub提前发布]
Delta病毒共染治疗由乙型肝炎引起的慢性肝炎。
Brancaccio G1，Gaeta GB2。
作者信息

1
    意大利帕多瓦大学分子医学系传染病。
2
    坎帕尼亚大学心理与身体健康系，意大利那不勒斯。电子地址：[email protected]。

抽象

慢性肝炎三角洲病毒感染的治疗仍未得到满足。全世界估计有20-40百万人被感染，其中大多数患有迅速发展的肝病。迄今为止，对于Delta肝炎，仅推荐使用基于IFN的疗法。应答率不能令人满意，此外，许多患者对IFN不耐受或不合格。近年来，已经开发出了针对病毒进入肝细胞的创新方法。抑制宿主酶法尼基转移酶，从而抑制病毒体的完全形成和释放；阻断HBsAg分泌，从而抑制病毒释放； IFN Lamda，比IFNα引起的不良反应要少。临床试验正在进行中，并取得了令人鼓舞的初步结果。

版权所有©2019.由Elsevier B.V.发布
关键词：

HBsAg释放阻滞剂：IFN Lambda；进入抑制剂乙型肝炎；三角洲肝炎PEG-IFN;烯丙基化抑制剂

结论：
    31541699
DOI：
    10.1016 / j.ijantimicag.2019.09.012