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VBI Vaccines Enters into License and Collaboration Agreement with Brii Biosciences for up to $129 Million plus Royalties to Develop a Functional Cure for Hepatitis B
Posted by Staff Writer on April 7, 2019 at 10:00 pm
Upon closing, VBI received gross proceeds of $11 million, consisting of an upfront payment and an equity investment at $3.05 per share from Brii Biosciences
VBI is eligible to receive an additional $117.5 million in potential milestone payments and potential double-digit royalties on commercial sales in the holding territory – China, Taiwan, Macau, and Hong Kong
CAMBRIDGE, Mass., Dec. 06, 2018 (GLOBE NEWSWIRE) — VBI Vaccines Inc. (NASDAQ: VBIV) (“VBI”), a commercial-stage biopharmaceutical company developing next-generation infectious disease and immuno-oncology vaccines, today announced That it entered into a license and collaboration agreement with Brii Biosciences, a company committed to serve patients' needs and improving public health in China, for the development of a functional cure for the treatment of chronic hepatitis B infection, using VBI's recombinant, protein- Based immuno-therapeutic, VBI-2601.
As part of the collaboration, Brii Bio paid VBI an upfront payment of $11 million, consisting of a $4 million upfront payment and a $7 million equity investment priced at $3.05 per share. VBI is also eligible to receive an additional $117.5 million in potential milestone payments , and potential double-digit royalties on commercial sales in the holding territory, which includes China, Hong Kong, Macau, and Taiwan.
"I am very excited to announce this partnership with Brii Bio, which leverages our hepatitis B expertise and marks our pipeline expansion into the therapeutic setting," said Jeff Baxter, President and CEO of VBI. "Brii Bio is uniquely positioned to accelerate infectious disease Drug development and commercialization in China due to their world-class leadership, investors, and foundational and strategic partnerships. We believe this collaboration creates a promising opportunity to quickly and effectively develop a cure for chronic hepatitis B patients."
"Chronic hepatitis B is one of the world's most serious infectious disease burdens, and one that is particularly endemic in China," said Dr. Zhi Hong, Ph.D., co-founder and CEO of Brii Bio. "We believe VBI's immuno -therapeutic has the potential to be a differentiated, and perhaps vital, component of a functional cure. This collaboration is a significant step forward as we work to deliver on our mission to improve public health in China.” Additional details were announced by Brii Bio Today.
Under the agreement, VBI and Brii Bio will collaborate in the development of the product through to completion of a proof-of-concept clinical trial in China, following which, Brii Bio will be responsible for funding for funding in the holding territory. Brii Bio Additional information regarding this deal can be found in VBI's associated Current Report on Form 8-K filed today with the US Securities and Exchange Commission (SEC) And available through the SEC's website at .
VBI-2601 has the potential to contribute to a functional cure by inducing and sustaining broad and effective immunity against Hepatitis B. VBI-2601 is uniquely formulated to target both B-cell and T-cell immunity through multiple mechanisms of action, including neutralizing the Circulating hepatitis B virus, blocking hepatitis B infection of hepatocytes mediated through Pre-S1, and enabling immune-mediated clearance of infected hepatocytes.
Hepatitis B is one of the world's most significant infectious disease threats with over 250 million people infected globally. Chronic infection can lead to cirrhosis of the liver, hepatocellular cancer, and other liver disease, making it a life-threatening global health problem. B therapies have proven to achieve a functional cure in less than 20 percent of those treated.
About VBI Vaccines Inc.
VBI Vaccines Inc. ("VBI") is a commercial-stage biopharmaceutical company developing a next generation of vaccines to address unmet needs in infectious disease and immuno-oncology. VBI's first marketed product is Sci-B-Vac®, a hepatitis B ( HBV) vaccine that mimics all three viral surface antigens of the hepatitis B virus; Sci-B-Vac® is approved for use in Israel and 10 other countries. VBI's eVLP Platform technology enables the development of enveloped virus-like particle (eVLP) vaccines That closely mimic the target virus to elicit a potent immune response. VBI is advancing a pipeline of eVLP vaccines, with lead programs in cytomegalovirus (CMV) and glioblastoma (GBM). VBI is headquartered in Cambridge, MA with research operations in Ottawa, Canada And research and manufacturing facilities in Rehovot, Israel. |
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发表于 2019-4-22 18:37
