治疗乙型肝炎的全球科学战略

StephenW

A global scientific strategy to cure hepatitis B

    Prof Peter A Revill, PhD
    Prof Francis V Chisari, MD
    Joan M Block, BSN
    Maura Dandri, PhD
    Adam J Gehring, MD
    Haitao Guo, PhD
    et al.
    Show all authors

Published:April 10, 2019DOI:https://doi.org/10.1016/S2468-1253(19)30119-0
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    Summary
    Introduction
    The HBV lifecycle
    Chronic hepatitis B and resolution of infection
    Immunise, test, and treat
    Monitoring and prevention of cancer
    Definitions of HBV cure
    Strategy 1: curing HBV infection without killing infected cells
    Strategy 2: inducing immune control to safely eliminate HBV-infected cells
    Coordinated clinical studies to advance HBV cure
    Conclusions
    Search strategy and selection criteria
    Supplementary Material
    References
    Article Info
    Figures

Summary
Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE-HBV) is a coalition of experts dedicated to accelerating the discovery of a cure for chronic hepatitis B. Following extensive consultation with more than 50 scientists from across the globe, as well as key stakeholders including people affected by HBV, we have identified gaps in our current knowledge and new strategies and tools that are required to achieve HBV cure. We believe that research must focus on the discovery of interventional strategies that will permanently reduce the number of productively infected cells or permanently silence the covalently closed circular DNA in those cells, and that will stimulate HBV-specific host immune responses which mimic spontaneous resolution of HBV infection. There is also a pressing need for the establishment of repositories of standardised HBV reagents and protocols that can be accessed by all HBV researchers throughout the world. The HBV cure research agenda outlined in this position paper will contribute markedly to the goal of eliminating HBV infection worldwide.

StephenW

治疗乙型肝炎的全球科学战略

    Peter A Revill教授，博士
    Francis V Chisari教授，医学博士
    Joan M Block，BSN
    Maura Dandri，博士
    Adam J Gehring，医学博士
    郭海涛博士
    等。
    显示所有作者

发布时间：2019年4月10日道：https：//doi.org/10.1016/S2468-1253（19）30119-0
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    摘要
    介绍
    HBV生命周期
    慢性乙型肝炎和感染的消退
    免疫，测试和治疗
    监测和预防癌症
    HBV治愈的定义
    策略1：治愈HBV感染而不杀死感染细胞
    策略2：诱导免疫控制以安全地消除HBV感染的细胞
    协调临床研究以促进HBV治愈
    结论
    搜索策略和选择标准
    补充材料
    参考
    文章信息
    数据

摘要
慢性乙型肝炎病毒（HBV）感染是与结核病，艾滋病毒和疟疾相同规模的全球公共卫生挑战。国际消除HBV联盟（ICE-HBV）是一个专家联盟，致力于加速发现慢性乙型肝炎的治疗方法。与来自全球的50多位科学家以及包括受影响人在内的主要利益相关者进行广泛磋商通过HBV，我们发现了我们目前的知识缺口以及实现HBV治愈所需的新策略和工具。我们认为研究必须集中于发现介入策略，这些策略将永久性地减少有效感染细胞的数量或永久沉默那些细胞中共价闭合的环状DNA，并且这将刺激HBV特异性宿主免疫应答，模仿HBV的自发消退感染。还迫切需要建立标准化HBV试剂和方案的储存库，这些储存库可供全世界所有HBV研究人员使用。本立场文件中概述的HBV治愈研究议程将为消除全球HBV感染的目标做出显着贡献。

StephenW

https://www.thelancet.com/journa ... 19)30119-0/fulltext