HBV相关肝细胞癌肝切除术后实际10年生存率的鉴定：一项多中

StephenW

J Gastrointest Surg. 2018 Oct 17. doi: 10.1007/s11605-018-4006-4. [Epub ahead of print]
Identification of Actual 10-Year Survival After Hepatectomy of HBV-Related Hepatocellular Carcinoma: a Multicenter Study.
Li ZL1, Yan WT1,2, Zhang J1, Zhao YJ1, Lau WY1,3, Mao XH4, Zeng YY5, Zhou YH6, Gu WM7, Wang H8, Chen TH9, Han J1, Xing H1, Wu H1, Li C1, Wang MD1, Wu MC1, Shen F10, Yang T11.
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Abstract
BACKGROUND:

Hepatitis B virus (HBV) infection is the leading cause of hepatocellular carcinoma (HCC) worldwide. The aim of the study was to identify the incidence and predictive factors of actual 10-year survival following liver resection of HBV-related HCC.
METHODS:

A Chinese multicenter database of patients undergoing curative hepatectomy of HBV-related HCC was reviewed. Patients who survived ≥ 10 years and patients who died < 10 years after surgery were compared and analyzed. Univariable and multivariable regression analyses were performed to identify predictive factors associated with 10-year survival.
RESULTS:

Among all enrolled 1016 patients, the actuarial 10-year survival rate was 24.1%, while the actual 10-year survival rate was 16.6%. There were 169 patients who survived at least 10 years after surgery and 688 who died within 10 years from surgery. These patients constituted the study population of this study. Multivariable regression analysis revealed that cirrhosis, preoperative HBV viral load > 104 copies/mL, maximum tumor size > 5 cm, multiple tumors, macroscopic and microscopic vascular invasion, postoperative HBV reactivation, and early recurrence (< 2 years after surgery) were independent risk factors associated with actual 10-year survival, while postoperative antiviral therapy, regular recurrence surveillance, and curative treatments for initial recurrence were independent protective factors.
CONCLUSIONS:

The actual 10-year survival after curative resection of HBV-related HCC was calculated to be 16.6%. Postoperative antiviral therapy and regular recurrence surveillance were independent protective factors associated with actual 10-year survival after liver resection of HBV-related HCC.
KEYWORDS:

Hepatectomy; Hepatitis B virus; Hepatocellular carcinoma; Overall survival

PMID:
    30334177
DOI:
    10.1007/s11605-018-4006-4

StephenW

J Gastrointest Surg。 2018年10月17日doi：10.1007 / s11605-018-4006-4。 [提前打印]
HBV相关肝细胞癌肝切除术后实际10年生存率的鉴定：一项多中心研究。
Li ZL1，Yan WT1,2，Zhang J1，Zhao YJ1，Lau WY1,3，Mao XH4，Zeng YY5，Zhou YH6，Gu WM7，Wang H8，Chen TH9，Han J1，Xing H1，Wu H1，Li C1，Wang MD1，吴MC1，沉F10，杨T11。
作者信息
抽象
背景：

乙型肝炎病毒（HBV）感染是全球肝细胞癌（HCC）的主要原因。该研究的目的是确定肝切除HBV相关HCC后实际10年生存率的发生率和预测因素。
方法：

本文综述了中国多中心数据库，该数据库包括接受HBV相关性肝癌根治性肝切除术的患者。对存活率≥10年的患者和术后<10年死亡的患者进行比较和分析。进行单变量和多变量回归分析以确定与10年存活相关的预测因素。
结果：

在所有登记的1016名患者中，精算10年生存率为24.1％，而实际10年生存率为16.6％。有169名患者在手术后存活至少10年，688名患者在手术后10年内死亡。这些患者构成了本研究的研究人群。多变量回归分析显示，肝硬化，术前HBV病毒载量> 104拷贝/ mL，最大肿瘤大小> 5 cm，多发肿瘤，肉眼和微观血管浸润，术后HBV再激活和早期复发（术后<2年）均为独立危险因素与实际10年生存率相关的因素，而术后抗病毒治疗，定期复发监测和初始复发的治愈性治疗是独立的保护因素。
结论：

HBV相关HCC根治性切除后的实际10年生存率计算为16.6％。术后抗病毒治疗和定期复发监测是肝切除HBV相关HCC后实际10年生存率的独立保护因素。
关键词：

肝切除术;乙型肝炎病毒;肝细胞癌;总体生存

结论：
    30334177
DOI：
    10.1007 / s11605-018-4006-4