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本帖最后由 StephenW 于 2018-8-18 18:43 编辑
Lenvatinib
Lenvatinib is a multikinase inhibitor of VEGF receptors 1-3, PDGF receptor alpha, and FGF receptors 1-4, among others.25 Currently approved for thyroid and kidney cancer, lenvatinib also was investigated as a first-line treatment for HCC. 8/16/18 The U.S. FDA has approved lenvatinib for first-line treatment of patients with unresectable HCC. In a phase III open-label noninferiority study conducted by Cheng and colleagues, patients (N=954) with BCLC stage B or C HCC and Child-Pugh A cirrhosis were randomly assigned to weight-based lenvatinib (8 or 12 mg) or sorafenib.26 Median overall survival was 13.6 and 12.3 months with lenvatinib and sorafenib, respectively (HR 0.92;95% CI, 0.79-1.06). Median progression-free survival was significantly longer with lenvatinib than sorafenib (7.4 months vs 3.7 months; <.00001). Lenvatinib also significantly increased time to progression (8.9 months vs 3.7 months; <.00001) and overall response rate (24% vs 9%; <.00001). The most common adverse effects in the lenvatinib treatment group were hypertension (42%), diarrhea (39%), decreased appetite (34%), weight loss (31%), and fatigue (30%).26 |
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