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新加坡主权财富基金GIC将向中国制药商Ascletis的香港IPO投资750

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发表于 2018-7-18 14:19 |显示全部帖子
Singapore sovereign wealth fund GIC to invest US$75 million in Chinese drug maker Ascletis’ Hong Kong IPO
PUBLISHED : Tuesday, 17 July, 2018, 9:29pm
UPDATED : Tuesday, 17 July, 2018, 11:03pm


Ascletis Pharma, the first biotechnology firm to file for an IPO in Hong Kong following recent listing reforms, has secured commitment from Singapore sovereign wealth manager GIC to become a cornerstone investor.
SCMP Today: Intl Edition

GIC will buy a fifth or US$75 million worth of Ascletis shares as the Hangzhou-based company seeks to raise between US$343 million and US$457 million from the initial public offering, according to the terms.

The company is offering 224.1 million shares at HK$12 to HK$16 each, potentially valuing the entire firm at up to US$2.32 billion. The shares are expected to start trading on August 1.

GIC will also be prohibited from selling its holding in the hepatitis C drug developer for six months from the listing date.

If demand substantially exceeds the base offering, up to 15 per cent more shares could be sold increasing the offer size to between US$394 million and US$526 million.

The company and GIC would not comment.

The retail offer for 10 per cent of the shares begins on Friday, and the price will be fixed next Wednesday.

Some 30 per cent of the listing proceeds has been earmarked for research and development of its pipeline of new drugs, while 25 per cent will be used to commercialise its Danoprevir and Ravidasvir drugs.

Danoprevir was exclusively licensed to Ascletis from Swiss pharmaceutical giant Roche five years ago, to develop, produce and commercialise the drug in the mainland, Hong Kong and Taiwan.

Ravidasvir was licensed from San Francisco-based Presidio Pharmaceuticals in 2014 for commercialisation in Greater China.

Ascletis expects to launch Danoprevir, the first hepatitis C cure developed by a Chinese firm by September 30, it said in a preliminary listing prospectus.

It has “demonstrated a far higher cure rate of 97 per cent, a shorter treatment duration of 12 weeks and a superior safety and tolerability profile”, the document said, adding that current drugs such as pegylated interferon and ribavirin have a success rate of about 60 per cent that takes between 48 and 72 weeks to treat.

Ascletis has completed phase three clinical trials and applied to regulators for the drug to be launched.

When combined with Ravidasvir, the cure rate rises to 99 per cent, it added.

Another 15 per cent of the proceeds will be deployed on licensing additional new drug candidates from other developers for further development and potential commercialisation.

The remaining 30 per cent will be used to fund clinical trials for another hepatitis C drug candidate ASC21 licensed from Swedish biotech firm Medivir a year ago, in-house drugs development for hepatitis B and fatty liver disease, and working capital.

Morgan Stanley, Goldman Sachs and China Merchants Securities are the deal’s joint sponsors.
This article appeared in the South China Morning Post print edition as: Soon-to-list Ascletis secures GIC as investor

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发表于 2018-7-18 14:19 |显示全部帖子
新加坡主权财富基金GIC将向中国制药商Ascletis的香港IPO投资7500万美元
出版时间:2018年7月17日星期二,下午9:29
更新时间:2018年7月17日星期二,晚上11:03


Ascletis Pharma是首家在近期上市改革后在香港申请首次公开募股的生物技术公司,已获得新加坡主权财富管理公司GIC的承诺,成为基石投资者。
SCMP Today:Intl Edition

根据条款,GIC将购买价值第五或价值7500万美元的Ascletis股票,因为总部位于杭州的公司试图通过首次公开募股筹集3.43亿美元至4.57亿美元。

该公司以每股12港元至16港元的价格发行2.241亿股股票,可能使整个公司估值高达23.2亿美元。该股票预计将于8月1日开始交易。

GIC也将被禁止在上市之日起六个月内出售其在丙型肝炎药物开发商中的持股。

如果需求大幅超过基准产品,则可以出售多达15%的股票,将报价规模增加到3.94亿美元至5.26亿美元之间。

该公司和GIC不予置评。

10%股票的零售报价从周五开始,价格将在下周三确定。

大约30%的上市收益专门用于研究和开发新药管道,而25%将用于将其Danoprevir和Ravidasvir药物商业化。

五年前,Danoprevir被瑞士制药巨头罗氏独家授权给Ascletis,在大陆,香港和台湾开发,生产和商业化该药物。

Ravidasvir于2014年获得旧金山Presidio Pharmaceuticals的许可,用于大中华区的商业化。

Ascletis预计将推出Danoprevir,这是中国公司在9月30日开发的第一种丙型肝炎治疗药物,它在一份初步的上市招股书中表示。

该文件称,它“显示出更高的治愈率97%,更短的治疗持续时间为12周,并具有更高的安全性和耐受性”,并补充说目前的药物如聚乙二醇化干扰素和利巴韦林的成功率约为60%需要48至72周的治疗时间。

Ascletis已完成第三阶段临床试验,并向监管机构申请推出该药物。

与Ravidasvir合用后,治愈率上升至99%。

另外15%的收益将用于许可其他开发商的其他新药候选人,以进一步开发和潜在的商业化。

其余30%将用于资助一年前从瑞典生物技术公司Medivir获得许可的另一种丙型肝炎候选药物ASC21的临床试验,乙肝和脂肪肝疾病的内部药物开发以及营运资金。

摩根士丹利,高盛和招商证券是该交易的联合发起人。
本文刊登在“南华早报”印刷版上:即将上市的Ascletis将GIC作为投资者

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