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This observation from the above study should be noted:
"This study had some limitations that should be addressed. Two electronic databases (ie, PubMed and ClinicalTrials.gov website) were utilized to search relevant clinical trials, although various databases are available. This limited data-base utilization also likely limited our opportunities to search additional valuable and relevant clinical trials. Almost all of the selected clinical trials mentioned that TDF and ETV were not likely to have significantly negative effects on renal functions. However, consistent results were not shown partially owing to the different characteristics of study subjects and various markers used to measure renal functions, which made the conducting of further meta-analysis difficult."
应注意以上研究的观察:
“这项研究有一些局限性应该解决,尽管有各种数据库可用,但是使用两个电子数据库(即PubMed和ClinicalTrials.gov网站)来搜索相关的临床试验,这种有限的数据库利用率也有可能限制我们的机会 几乎所有选定的临床试验都提到,TDF和ETV不太可能对肾功能有显着的负面影响,但是由于研究对象和各种不同的特征,不一致的结果没有显示出来 用于测量肾功能的标记物,使进一步的荟萃分析难以进行。 |
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