乙型肝炎病毒细胞凋亡的干扰。 林S1，张毅2。

StephenW

Viruses. 2017 Aug 18;9(8). pii: E230. doi: 10.3390/v9080230.
Interference of Apoptosis by Hepatitis B Virus.Lin S1, Zhang YJ2.
Author information
1Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA. [email protected].2Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA. [email protected].

AbstractHepatitis B virus (HBV) causes liver diseases that have been a consistent problem for human health, leading to more than one million deaths every year worldwide. A large proportion of hepatocellular carcinoma (HCC) cases across the world are closely associated with chronic HBV infection. Apoptosis is a programmed cell death and is frequently altered in cancer development. HBV infection interferes with the apoptosis signaling to promote HCC progression and viral proliferation. The HBV-mediated alteration of apoptosis is achieved via interference with cellular signaling pathways and regulation of epigenetics. HBV X protein (HBX) plays a major role in the interference of apoptosis. There are conflicting reports on the HBV interference of apoptosis with the majority showing inhibition of and the rest reporting induction of apoptosis. In this review, we described recent studies on the mechanisms of the HBV interference with the apoptosis signaling during the virus infection and provided perspective.


KEYWORDS: X protein; apoptosis; hepatitis B virus (HBV); hepatocellular carcinoma (HCC)

PMID:28820498DOI:10.3390/v9080230

StephenW

病毒。 2017年8月18日; 9（8）。 pii：E230。 doi：10.3390 / v9080230。
乙型肝炎病毒细胞凋亡的干扰。
林S1，张毅2。
作者信息

1
    分子病毒学实验室，VA-MD兽医学院和马里兰州马里兰州大学病原生物研究所，马里兰大学公园，MD 20742，美国。 [email protected]。
2
    分子病毒学实验室，VA-MD兽医学院和马里兰州马里兰州大学病原生物研究所，马里兰大学公园，MD 20742，美国。 [email protected]。

抽象

乙型肝炎病毒（HBV）导致肝脏疾病，这是人类健康的一贯问题，导致全世界每年有超过一百万人死亡。世界范围内大部分肝细胞癌（HCC）病例与慢性HBV感染密切相关。凋亡是程序性细胞死亡，并且在癌症发展中经常被改变。 HBV感染干扰凋亡信号传导，促进HCC进展和病毒增殖。 HBV介导的细胞凋亡改变是通过干扰细胞信号通路和表观遗传学调节来实现的。 HBV X蛋白（HBX）在凋亡的干扰中起主要作用。关于HBV干扰细胞凋亡的报告相互矛盾，其中多数显示抑制和其余报告诱导凋亡。在本次综述中，我们介绍了病毒感染期间HBV干扰细胞凋亡信号的机制的近期研究，并提供了观察。
关键词：

X蛋白;细胞凋亡;乙型肝炎病毒（HBV）;肝细胞癌（HCC）

结论：
    2882​​0498
DOI：
    10.3390 / v9080230