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Oncogenic Role of Tumor Viruses in Humans
To cite this article:
Akram Nimrah, Imran Muhammad, Noreen Mamoona, Ahmed Fayyaz, Atif Muhammad, Fatima Zareen, and Bilal Waqar Ahmed. Viral Immunology. January 2017, 30 (1): 20-27. Doi: 10.1089 / vim.2016.0109.
Published in Volume: 30 Issue 1: January 1, 2017
Online Ahead of Print: November 10, 2016
Full Text HTML Full Text PDF (377.5 KB) Full Text PDF with Links (342.5 KB)
Author information
Nimrah Akram, 1 Muhammad Imran, 1 Mamoona Noreen, 2 Fayyaz Ahmed, 1 Muhammad Atif, 1 Zareen Fatima, 3 and Ahmed Bilal Waqar1
1Department of Medical Laboratory Sciences (DMLS), Faculty of Health and Allied Sciences (FHAS), Imperial College of Business Studies (ICBS), Lahore, Pakistan.
2Department of Zoology, The Women University Multan, Multan, Pakistan.
3Department of Radiological Sciences and Medical Imaging (DRSMI), FHAS, ICBS, Lahore, Pakistan.
Address correspondence to:
Dr. Muhammad Imran
Department of Medical Laboratory Sciences (DMLS)
Faculty of Health and Allied Sciences (FHAS)
Imperial College of Business Studies (ICBS)
Lahore 54000
Pakistan
E-mail: [email protected]
ABSTRACT
Viruses are the intracellular pathogens that reproduce only in the living cell and manipulate the cellular machinery to produce more viruses. Viral replications can affect cellular genes of the host in multiple cancerous ways. Approximately, 20% of all human oncogenesis is caused by cancer-causing As well as the major host cells are transformed into cancerous cells on the basis of host genetic variability. . Oncogenic viruses encode genes that cause viral replication and transformation of the host cells to produce viral proteins and protein complexes. From the basic viral infection to tumorigenesis is length of due to the involvement of factors like Fas complications, cellular mutations, and exposure to other (HCV), Epstein-Barr virus (EBV), Human papilloma virus (HPV), Kaposi's sarcoma herpes virus (KSHV), Hepatitis B virus (HBV), Hepatitis C virus (HCV) And Human T lymphotrophic virus 1 (HTLV-1). This review article summarizes advanced knowledge related to human oncogenic viruses and the molecular mechanisms that lead to tumorigenesis in humans.
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