乙型肝炎病毒感染和减少非酒精性脂肪性肝病的风险：队列

StephenW

Steatohepatitis/Metabolic Liver Disease
Hepatitis B virus infection and decreased risk of nonalcoholic fatty liver disease: A cohort study
Authors

    First published: 30 December 2016Full publication history
    DOI: 10.1002/hep.28917View/save citation
    Cited by: 0 articles

    Potential conflict of interest: Nothing to report.

Abstract

The presence of an association between chronic hepatitis B virus (HBV) infection and fatty liver is controversial. We examined the association between HBV infection and the development of nonalcoholic fatty liver disease (NAFLD). We conducted a cohort study of 83,339 participants without NAFLD at baseline who underwent serologic testing for hepatitis B surface antigen (HBsAg) between 2002 and 2006 and were followed annually or biennially until December 2014. NAFLD was defined as the presence of ultrasonographic fatty liver in the absence of excessive alcohol use or other identifiable causes. We used a parametric Cox model to estimate adjusted hazard ratios with 95% confidence intervals of incident NAFLD. During 484,736.1 person-years of follow-up, 20,200 incident NAFLD cases were identified. In models adjusted for age, sex, year of visit, smoking status, alcohol intake, regular exercise, education level, and body mass index, the adjusted hazard ratio (95% confidence interval) for incident NAFLD comparing HBsAg-positive to HBsAg-negative participants was 0.83 (0.73-0.94). After introducing HBV infection and confounders (including homeostasis model assessment of insulin resistance and metabolic factors) as time-dependent exposures, the association between HBV infection and decreased risk of incident NAFLD was attenuated but persisted. These associations were consistently observed across clinically relevant, prespecified subgroups. Conclusion: In this large cohort of apparently healthy Korean adults, HBsAg seropositivity was associated with lower risk of developing NAFLD, indicating a possible effect of HBV infection on the pathogenesis of NAFLD development. (Hepatology 2017;65:828-835).

StephenW

脂肪性肝炎/代谢性肝病
乙型肝炎病毒感染和减少非酒精性脂肪性肝病的风险：队列研究
作者

首次发布：30十二月2016完整的出版历史
DOI：10.1002 / hep.28917查看/保存引文
引用：0文章

潜在的利益冲突：没有报告。

抽象

慢性乙型肝炎病毒（HBV）感染和脂肪肝之间的每个关联的发生率是有争议的。我们审查了感染和非酒精性脂肪性肝病（NAFLD）的发展之间的关联。我们对83,339名没有NAFLD的受试者进行了队列研究，他们在2002年至2006年之间接受了乙型肝炎表面抗原（HBsAg）的血清学测试，并在2014年12月之前或每两年进行一次。NAFLD被定义为在不存在超声波脂肪肝过度饮酒或其他可识别的原因。使用参数Cox模型估计调整的风险比，对事件NAFLD的置信度为95％。在484,736.1人年的随访期间，确定了20,200例NAFLD事件。在针对年龄，性别，访视年，吸烟状态，酒精摄入，正常运动，教育水平和身体质量指数调整的模型中，针对事件NAFLD HBsAg阳性的HBsAg阴性参与者的95％置信区间（95％置信区间）是0.83（0.73-0.94）（包括胰岛素抵抗和代谢因素的稳态模型评估）作为时间依赖性暴露，HBV感染和病例NAFLD风险降低之间的关联减弱但持续。这些关联更新与完全临床相关的，预先指定的亚组。这个大群人的平均韩国成年人，HBsAg血清阳性与发展NAFLD的较低风险相关联，表明HBV感染对NAFLD发展的发病机制的可能影响。 （Hepatology2017; 65：828-835）。