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肝胆相照论坛 论坛 学术讨论& HBV English arc520治疗的患者已见免疫恢复迹象!
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arc520治疗的患者已见免疫恢复迹象!   [复制链接]

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发表于 2015-11-15 13:13 |只看该作者
回复 重韧 的帖子

不是小道消息!

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风雨同舟

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发表于 2015-11-15 13:39 |只看该作者
On analyst day Stephen Locarnini, M.D., Ph.D said:

“We are already beginning to see early signs of immune recovery in some of the treated patients we are watching very closely that space to see what will be the final outcome”
日行一善(百善孝为先)

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发表于 2015-11-15 14:00 |只看该作者
马克

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发表于 2015-11-15 16:25 |只看该作者
好消息

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发表于 2015-11-15 16:44 |只看该作者
好消息

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风雨同舟

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发表于 2015-11-15 18:27 |只看该作者
Arrowhead to Present at Upcoming Conferences
PASADENA, Calif.--(BUSINESS WIRE)-- Arrowhead Research Corporation (NASDAQ: ARWR), a biopharmaceutical company developing targeted RNAi therapeutics, today announced that the company will make presentations at the following upcoming events.
The Liver Meeting 2015®, 66th Annual Meeting of the American Association for the Study of Liver Disease (AASLD) - San Francisco, November 13-17, 2015
November 15, 3:15 p.m. PST - Christine Wooddell, Ph.D., Arrowhead group leader will deliver an oral presentation titled, "Reductions in cccDNA under NUC and ARC-520 therapy in chimpanzees with chronic hepatitis B virus infection implicate integrated DNA in maintaining circulating HBsAg"November 16, 8:00 a.m. - 5:30 p.m. PST - Man-Fung Yuen, M.D., Ph.D., chair of gastroenterology and hepatology, The University of Hong Kong, and deputy chief of service, Queen Mary Hospital department of medicine, Hong Kong, will deliver a late-breaking poster presentation titled, "ARC-520 produces deep and durable knockdown of viral antigens and DNA in a phase II study in patients with chronic hepatitis B"
November 16, 6:30 p.m. PST - Arrowhead management will host an Analyst and Investor Reception to discuss ARC-520 and key data being presented at the conference
November 17, 8:00 a.m. - 12:00 p.m. PST - Christine Wooddell, Ph.D., Arrowhead group leader will deliver a poster presentation titled, "Monthly dosing of ARC-520 in chronically hepatitis B virus infected chimpanzees produces rapid, deep and durable reductions in circulating viral antigens"Jefferies Autumn 2015 Global Healthcare Conference - London, UK, November 18-19, 2015
November 19, 2:40 p.m. GMT - Chris Anzalone, Ph.D., Arrowhead president and chief executive officer, will present a company overviewPiper Jaffray 27th Annual Healthcare Conference - New York, December 1-2, 2015
December 2, 3:00 p.m. EST - Chris Anzalone, Ph.D., Arrowhead president and chief executive officer, will present a company overview in a fireside chat with Ted Tenthoff, senior research analyst, Piper JaffrayHEP DART 2015 - Wailea, Hawaii, December 6-10, 2015
December 2, 6:40 p.m. HST - Bruce Given, M.D., Arrowhead chief operating officer, will deliver an oral presentation titled, "New insights on HBV biology from the ARC-520 development program"December 8, 4:00 - 5:30 p.m. HST - Christine Wooddell, Ph.D., Arrowhead group leader will deliver a poster presentation titled, "Sustained reduction in HBsAg, HBV DNA and HBeAg seroconversion in a chronically HBV-infected chimpanzee treated with nucleoside analog/ARC-520 combination therapy"
日行一善(百善孝为先)

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发表于 2015-11-15 19:43 |只看该作者
啥叫免疫恢复!是不是长久和病毒共存啊!

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才高八斗

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发表于 2015-11-15 20:17 |只看该作者
pppq123 发表于 2015-11-15 19:43
啥叫免疫恢复!是不是长久和病毒共存啊!

不是, 所有患者的免疫系统能够控制或清除乙肝病毒, 但乙肝病毒已经已经进化方法来逃避/抑制HBV特异性免疫攻击 - 大批量血清中的病毒粒子和乙肝表面抗原. NUCs可以显著降低血清中的病毒颗粒,我们需要药物显著降低血清中的HBsAg(如REP9AC/ ARC521).那么,我们应该可以恢复HBV特异性免疫.

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发表于 2015-11-16 08:27 |只看该作者
这样说,如果配合核苷药物用,这个应该有效果呢!
免疫恢复,这才是最后的结果。一点也没错。 看到希望了哈哈!!

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发表于 2015-11-16 15:32 |只看该作者
祈求上苍保佑
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