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回复 baobao7676 的帖子
Both aminotransferases are highly concentrated in the liver. AST is also diffusely represented in the heart, skeletal muscle, kidneys, brain and red blood cells, and ALT has low concentrations in skeletal muscle and kidney;21 an increase in ALT serum levels is, therefore, more specific for liver damage. In the liver, ALT is localized solely in the cellular cytoplasm, whereas AST is both cytosolic (20% of total activity) and mitochondrial (80% of total activity).22 Zone 3 of the hepatic acinus has a higher concentration of AST, and damage to this zone, whether ischemic or toxic, may result in greater alteration to AST levels. Aminotransferase clearance is carried out within the liver by sinusoidal cells.23 The half-life in the circulation is about 47 hours for ALT, about 17 hours for total AST and, on average, 87 hours for mitochondrial AST.4
既转氨酶高度集中在肝脏中。AST也漫在心脏,骨骼肌,肾脏,脑和红血细胞为代表,和ALT具有低浓度的骨骼肌和肾;[21]的增加的ALT血清水平,因此,更具体为肝脏损伤。在肝脏中,ALT完全是定位于细胞质,而AST既是胞质(总活性的20%)和线粒体(80%总活性的)。肝腺泡[22]3区具有的AST的浓度较高和损坏到该区域,不论缺血或毒性,可能会导致更大的改动AST水平。转氨酶间隙进行肝由正弦细胞内。[23]的半衰期在循环中是约47小时的ALT,约17小时,总AST和,平均87个小时为线粒体的AST。[4]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545762/ |
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