EASL2015:在25羟基维生素D水平相关性 和肝纤维化评估的瞬时弹

StephenW

P0514
THE CORRELATION BETWEEN 25-HYDROXYVITAMIN D LEVEL
AND LIVER FIBROSIS ASSESSED BY TRANSIENT ELASTOGRAPHY
IN PATIENTS WITH COMPENSATED CHRONIC LIVER DISEASE
Y.S. Kim1, S.G. Kim1, B.J. Ko1, S.W. Jeong2, J.Y. Jang2, Y.D. Kim3,
G.J. Cheon3, H.S. Kim4, B.S. Kim1, S.M. Kim1. 1Soonchunhyang
university Bucheon hospital, school of medicine, Bucheon,
2Soonchunhyang university Seoul hospital, school of medicine, Seoul,
3Gangneung Asan hospital, Ganggeung, 4Soonchunhyang university
Cheonan hospital, school of medicine, Cheonan, Korea, South
E-mail: [email protected]
Background and Aims: 25-hydroxyvitamin D [25(OH)D3]
deficiency has been known to be prevalent in chronic liver
disease (CLD). Low 25(OH)D3 serum levels were correlated with an
increase of liver fibrosis. The purpose of this study was to evaluate
correlation between 25(OH)D3 level and liver fibrosis assessed by
transient elastography (TE) in patient with compensated CLD.
Methods: From January 2013 to June 2014, the measurement of
25(OH)D3 serum levels and liver stiffness using TE were done in
260 CLD patients. Among them, 207 CLD patients were enrolled in
this study after excluding the patients with decompensated liver
disease.
Results: The mean age of patients was 48 years and 151 (72.9%)
patients were male. The most common etiology was chronic
hepatitis B (110, 53.1%), followed by chronic hepatitis C (15,
7.2%), non-alcoholic fatty liver disease (25, 12.1%), alcohol (41,
19.8%) and others (16, 7.7%). The median liver stiffness value was
6.8 kPa (Inter-quartile range: 5–11.5) and mean 25(OH)D3 level
was 12.68 ng/ml (standard deviation: 9.1–18.57). The number of
patients with 25(OH)D3 deficiency (<20 ng/ml), severe 25(OH)D3
deficiency (<10 ng/ml) were 94 (45.4%) and 72 (34.8%) respectively.
Advanced liver fibrosis defined by TE (9.5 kPa) was 75 (36.2%). There
was a significantly correlation between 25(OH)D3 deficiency and
liver stiffness (r = −0.204, p<0.003). On the multivariate analysis,
associated with advanced liver fibrosis severe 25(OH)D3 deficiency
[adjusted odds ratio (aOR) 3.92, 95% confidence interval (CI) 1.70–
9.01, p = 0.001], Gamma GT [aOR 1.004, 95% CI 1.00–1.007, p = 0.041],
and FIB4 [aOR 2.01, 95% CI 1.43.-2.83, p<0.001] were independently
significant factors.
Conclusions: In patients with compensated CLD, there was a close
correlation between 25(OH)D3 level and liver stiffness assessed by
TE. Severe vitamin D deficiency was independently associated with advanced liver fibrosis.

StephenW

P0514
在25羟基维生素D水平相关性
和肝纤维化评估的瞬时弹性
在代偿期慢性肝病病人
Y.S. Kim1，S.G。Kim1，B.J. KO1，S.W. Jeong2，J.Y. Jang2，Y.D. Kim3，
G.J. Cheon3，H.S. Kim4，B.S. Kim1，S.M Kim1。 1Soonchunhyang
大学富川医院，医学院，富川，
2Soonchunhyang首尔大学医院，医学院，首尔，
3Gangne​​ung峨山医院，Ganggeung，4Soonchunhyang大学
天安医院，医学院，天安，韩国
电子邮件：[email protected]
背景和目的：25-羟维生素D [25（OH）D3]
不足已经知道在慢性肝病被弥漫
疾病（CLD）。低25（OH）D 3的血清水平与一个
增加肝纤维化。本研究的目的是评估
25之间的相关性（OH）D3由水平和肝纤维化评估
瞬时弹性成像（TE）的患者补偿CLD。
方法：从2013年1月至2014年6月，测量
25（OH）D 3的血清水平和使用的TE肝脏硬度是在完成
260 CLD的患者。其中，207 CLD患者参加
这项研究排除了患者的肝脏失代偿后，
疾病。
结果：患者的平均年龄为48岁和151（72.9％）
患者为男性。最常见的病因是慢性
乙型肝炎（110，53.1％），其次是慢性丙型肝炎（15，
7.2％），非酒精性脂肪肝疾病（25，12.1％），醇（41，
19.8％）和其他（16，7.7％）。中位数肝脏硬度值
6.8千帕（间四分范围：5-11.5），平均25（OH）D3水平
物12.68毫微克/毫升（标准偏差：9.1-18.57）。数
例25（OH）D 3缺乏症（<20毫微克/毫升）中，重度25（OH）D3的
缺乏症（<10毫微克/毫升）分别为94（45.​​4％）和72（34.8％）。
由TE（9.5千帕）定义的晚期肝纤维化是75（36.2％）。那里
为25（OH）D 3和不足之间的相关性显著
肝脏硬度相关（r = -0.204，P <0.003）。在多变量分析，
拥有先进的肝纤维化有关的严重25（OH）D3缺乏症
[校正比值比（AOR）3.92，95％置信区间（CI）1.70-
9.01，P = 0.001]，伽玛GT [AOR 1.004，95％CI 1.00-1.007，P = 0.041]，
和FIB4 [AOR 2.01，95％CI 1.43.-2.83，P <0.001]分别独立
显著的因素。
结论：在患者的补偿CLD，有一个接近
25之间的相关性（OH）D3由水平和肝脏硬度评估
TE。严重的维生素D缺乏独立与先进的肝纤维化。