乙肝药物

newchinabok

		COMPANY	STATUS
FAMILY/DRUG NAME MECHANISM COMPANY STATUS Interferons - Mimic naturally-occurring, infection-fighting immune substance produced in the body Intron A (Interferon alfa-2b Immunomodulator Merck, Whitehouse Station, NJ FDA Approved 1991 Pegasys (Peginterferon alfa-2a) Immunomodulator Genentech, South SanFrancisco, CA FDA Approved 2005 There are other brands of interferon approved for HCV treatment, but they have not been FDA-approved for HBV: Wellferon (Glaxo), Roferon(Hoffman-La Roche), and Infergen (Amgen) Nucleoside Analogues -  Interfere with the viral DNA polymerase enzyme used for hepatitis B virus reproduction Epivir-HBV (Lamivudine) Inhibits viral DNA polymerase GlaxoSmithKline Philadelphia, PA FDA Approved 1998 Hepsera (Adefovir Dipivoxil) Inhibits viral DNA polymerase Gilead Foster City, CA FDA Approved 2002 Baraclude (Entecavir) Inhibits viral DNA polymerase Bristol-Myers Squibb Princeton, NJ FDA Approved 2005 Tyzeka Sebivo (Europe) (Telbivudine) Inhibits viral DNA polymerase Novartis, Switzerland FDA Approved 2006 Viread (Tenofovir) Inhibits viral DNA polymerase Gilead Foster City, CA FDA Approved 2008 Clevudine (L-FMAU) Inhibits viral DNA polymerase Bukwang South Korea Eiasai, Japan Approved S. Korea 2006 (Levovir) Besifovir (LB80380) Inhibits viral DNA polymerase LG Life Sciences, S. Korea Phase II AGX-1009 Prodrug of Tenofovir Agenix, Australia Phase I, China Non-Nucleoside Antivirals -  Interfere with proteins involved in viral reproduction NOV-205 (BAM 205) Small Molecule Novelos Newton, MA Approved in Russia Myrcludex B Entry Inhibition Myr-GmbH, Germany Phase IIa, Russia HAP Compound Bay 41-4109 Inhibits viral nucleocapsid AiCuris, Germany Phase I REP 9AC      HBsAg Release Inhibitor REPLICor Inc. Montreal, Quebec Phase I Alinia (Nitazoxanide) Small Molecule Romark Labs Tampa, FL Preclinical dd-RNAi compound Gene silencing Benitec, Australia and Biomics, China Preclinical ARC-520 RNAi gene silencer Arrowhead Research, Pasadena, CA Clinical Phase I NVR-1221 Capsid inhibitor Novira Therapeutics, Doylestown, PA Preclinical IHVR-25 cccDNA inhibitor Baruch S. Blumberg Intsitute, Doylestown, PA Preclinical Non-Interferon Immune Enhancers -  Boost T-cell infection-fighting immune cells and natural interferon production Zadaxin (Thymosin alpha-1) Immune stimulator SciClone San Mateo, CA Orphan drug approval in US for liver cancer CYT107 (Interleukin-7) Immunemodulator Cytheris, Paris, France Phase I/IIa DV-601 HBV surface and core antigens Dynavax, Berkeley, CA Phase Ib HBV Core Antigen Vaccine Therapeutic HBV vaccine Emergent Europe, U.K. Phase I GS-9620 TLR7 agonist Gilead Foster City, USA Phase I GI13000 HBV Antigen Globe Immune Louisville, CO Preclinical with Gilead	Immunomodulator	Merck, Whitehouse Station, NJ	FDA Approved 1991