乙型肝炎突变只有男性看到，肝癌的风险增加

StephenW

Hepatitis B Mutation Seen in Only Men, Increased Risk of Liver Cancer

A recent study looks at a form of hepatitis B that is only found in men and may explain higher rates for certain types of cancer.



According to a team of researchers from Seoul National University in Korea, they identified a mutation from the hepatitis B virus that seems to appear only in men and may explain why HBV-infected males are roughly five times more likely than HBV-infected women to develop certain types of liver cancer.

"This is the first mutation found that can explain the gender disparity in incidence of hepatocellular carcinoma," Bum-Joon Kim of Seoul National University, Korea, an author on the study said, via a press release.

Researchers collected and analyzed serum samples from approximately 292 patients found with chronic HBV infections that visited one of three hospitals in Korea from 2003 to 2005. Previous findings have suggested that a gene mutation known as W4P/R that was associated with a higher incidence of liver cancer and cirrhosis, yet the same mutation was also significant associated with severe liver disease that was only found in male patients.

Investigators believe that this mutation may hold promise for predicting the progression of both cirrhosis and liver cancer, as only 67 of the 292 samples came from women in the studies' findings.

As HBV continues to be a global health problem, with over 350 million chronic carriers, infection prevalence ranges from less than half of the United States to 10 percent of Asia and more than 15 percent of Africa. Transmission can come through unprotected sexual activity, drug abuse and childbirth. Make sure to take accuarte measure to protect yourself.

More information regarding the study can be found via the Journal of Clinical Microbiology.

StephenW

乙型肝炎突变看到只有男性，肝癌的风险增加
最近的一项研究着眼于B型肝炎只发现在男性和某些类型的癌症，可能解释率较高的一种形式。



根据一队在韩国首尔国立大学的研究人员，他们确定了，似乎只出现在男性乙肝病毒变异，也许可以解释为什么HBV感染的男性大约五倍可能比感染乙肝病毒的妇女发展某些类型的肝癌。

“这是第一次突变可以解释肝癌发病率中的两性差距， ”范金俊，韩国，首尔国立大学这项研究的作者说，通过一份新闻稿。

研究人员收集和分析血清样本中发现约292例慢性HBV感染，参观了2003年至2005年在韩国的三家医院之一。研究结果表明，伴有严重的肝脏疾病，仅见于男性患者的基因突变被称为的W4P / R是与肝癌和肝硬化的发病率较高，但相同的突变也显着。

调查人员认为，这种突变也有望用于预测肝硬化和肝癌的进展，只有67 292样本研究发现，女性在来自。

由于乙肝病毒仍然是一个全球性的健康问题，有超过350万的慢性携带者，感染率范围从不到美国的一半，亚洲10％和超过15 ％的非洲。传输可以通过无保护的性行为，滥用药物和分娩。确保采取accuarte措施来保护自己。

有关研究的更多信息，可以发现通过临床微生物学杂志