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- 17064 元
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- 2007-6-26
- 最后登录
- 2017-11-25
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In February 2009, the company received an IRB approval to initiate phase I/II trial in patients with HCV and HBV
infections in Asia. The subjects would receive escalating doses of the drug to determine its safe and effective
dose. The primary endpoints were reduction in serum viral titers and serum surface antigen levels and at that
time, patient enrollment was underway [ 1087461]; in March 2009, the company initiated dosing of patients in
its phase I/II trial [ 1087465]. In March 2010, the interim data showed that the drug cleared the serum HBsAg
within the first 12 weeks of treatment by detecting the anti- HBsAg antibodies. These results demonstrated that
sustained reductions in serum HBV titers may be due to improved immune response. The company planned to
present this data in the 20th annual meeting of the APASL in Beijing, China |
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