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本帖最后由 风雨不动 于 2012-4-14 14:46 编辑
Eur J Gastroenterol Hepatol. 2011 Sep 19. [Epub ahead of print]
Correlation between intrahepatic hepatitis B virus cccDNA levels and other
activity markers in patients with HBeAg-negative chronic hepatitis B
infection.
Guner R, Karahocagil M, Buyukberber M, Kandemir O, Ural O, Usluer G, Inan
D, Koksal I, Baykam N, Hizel K, Yamazhan T, Esen S, Tasyaran MA.
Source
aAnkara Ataturk Education and Research Hospital, Clinic of Infectious
Diseases and Clinical Microbiology, Ankara bDepartments of Infectious
Diseases and Clinical Microbiology cDepartment of Gastroenterology, Faculty
of Medicine, Yuzuncu Yil University, Van dDepartment of Infectious Diseases
and Clinical Microbiology, Faculty of Medicine, Mersin University, Mersin
eDepartment of Infectious Diseases and Clinical Microbiology, Faculty of
Medicine, Selcuk University, Konya fDepartment of Infectious Diseases and
Clinical Microbiology, Faculty of Medicine, Osman Gazi University,
Eskisehir gDepartment of Infectious Diseases and Clinical Microbiology,
Faculty of Medicine, Akdeniz University, Antalya hDepartment of Infectious
Diseases and Clinical Microbiology, Faculty of Medicine, Karadeniz
Technical University, Trabzon iAnkara Numune Education and Research
Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Ankara
jDepartment of Infectious Diseases and Clinical Microbiology, Faculty of
Medicine, Gazi University, Ankara kDepartment of Infectious Diseases and
Clinical Microbiology, Faculty of Medicine, Ege University, Izmir
lDepartment of Infectious Diseases and Clinical Microbiology, Faculty of
Medicine, Ondokuz Mayis University, Samsun, Turkey.
Abstract
OBJECTIVE:
The aim of this study was to demonstrate the relation between intrahepatic
(IH) hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) levels
and the other HBV replicative intermediates and hepatocyte expression of
HBV antigens.
PATIENTS AND METHODS:
Patients with hepatitis B surface antigen (HBsAg) positivity, hepatitis B
early antigen negativity, serum HBV DNA levels 10 copies/ml or more, and
constantly or intermittently increased alanine aminotransferase levels were
included.
RESULTS:
Fifty-nine patients were included. There was a good correlation between the
levels of IH HBV cccDNA and serum HBV DNA (P<0.001). Serum HBsAg levels
were weakly correlated with IH HBV cccDNA levels and moderately correlated
with serum HBV DNA (r=0.322, P=0.017; r=0.489, P=0.001, respectively).
There were no significant correlation between serum HBsAg level and
histologic activity index groups (P=0.691), but stage 0, 1, and greater
than 2 fibrosis groups were positively correlated with serum HBsAg levels
(P=0.019). IH cccDNA and serum HBV DNA were significantly different in
hepatitis B core antigen staining groups (P=0.008 and <0.001, respectively)
but there was no significant correlation between HBsAg staining groups and
HBV replication markers. There was a weak correlation between serum HBsAg
levels and IH HBsAg and hepatitis B core antigen levels (r=0.333, P=0.012;
r=0.366, P=0.006, respectively). In multivariate analysis, alanine
aminotransferase, age, fibrosis stage, and serum HBsAg quantitation were
the most important factors predicting IH HBV cccDNA level.
CONCLUSION:
Histopathologic damage, serum HBV DNA levels, and IH HBV replication
markers have a more complex and dynamic process. However, both serum and IH
HBV replication markers provide important knowledge about the activity of
the disease.
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发表于 2011-9-27 20:22
