鲨鱼体内可提炼神奇药物 或将治愈癌症(包括乙肝)

cwy121

回复 候月 的帖子

莫非你有艾滋？

V友

我坚信治愈乙肝不会等得太久了

kaorusai

但是根据一直以来测试的安全记录，扎斯洛夫教授预计人体临床实验可以在一年之内展开。......
为什么现在才实验啊......急死我们这些人了。不过这些报道很多......真希望有一个能成功

蔡小楠

是好东西，不知道真的有效吗，能时候我们能用上呢？

西安狂人

希望在有生之年  看到一个有效的 。呵呵

三国杀

阻断哪个阶段

StephenW

studyforhope 在Medhelp上 回答 Squalamine问题:

[stephenw]:
What is your view on Squalamine , the molecule that interferes with the surface membrane of many types of cells, including the hepatocytes?

[studyforhope]:
Thanks for the PNAS paper re squalamine. I had it, but did not pay detailed attention yet to the in vitro testing on HBV. The testing was done  in a somewhat  strange format, normally you expect IC 50 and IC90 in micromols.
It appears that the anti HBV activity is not very strong. This compound will have limiting toxicity, since it alters the electrical charge on the cells membrane by incorporating a cholesterol like molecule with a plus charge due to the amine group, that will tend to neutralize the normal negative charge due to the phospholipid head groups. This will lead to profound changes in the functionality of the mem brane and the proteins associated with it, which can, hopefully disturb viral mechanisms before fundamental cell mechanisms are dangerously influenced.
At 20microgram/ml they found already cytotoxic changes in the test system.


It would be good to see a duck or woodchuck study with this compound.