血清乙肝表面抗原水平预测e抗原Seroconverters的表面抗原丢失

把握当下

StephenW 发表于 2011-8-12 13:07
回复 把握当下 的帖子

"我的理解对吗？" - No, I stand by my previous explanation. What you interpret  ...

Alright, at least we can know the HBsAg levels <100 IU/mL is very good news.

I know I'd surely be very happy if my  HBsAg levels can be detected(<250IU/ml).

StephenW

把握当下 发表于 2011-8-12 21:08
Alright, at least we can know the HBsAg levels

And don't worry too much if it  is > 250

StephenW

[A slightly different abstract]

<http://onlinelibrary.wiley.com/doi/10.1002/hep.24615/abstract>

Viral Hepatitis
Determinants of spontaneous surface antigen loss in HBeAg-negative patients
with a low viral load

Tai-Chung Tseng1,3,7, Chun-Jen Liu2,3, Hung-Chih Yang2,6, Tung-Hung Su2,3,
Chia-Chi Wang1,7, Chi-Ling Chen3, Stephanie Fang-Tzu Kuo8, Chen-Hua Liu2,3,
Pei-Jer Chen2,3, Ding-Shinn Chen2,3, Jia-Horng Kao2,3,4,5,*,†DOI:
10.1002/hep.24615

Copyright © 2011 American Association for the Study of Liver Diseases
Issue

Hepatology
Accepted Article (Accepted, unedited articles published online for future
issues)

Abstract

Background & Aims:
Loss of hepatitis B surface antigen (HBsAg) usually indicates the cure of
hepatitis B virus (HBV) infection. In spontaneous hepatitis B e antigen
(HBeAg) seroconverters, lower serum HBsAg and HBV DNA levels have been
shown to be associated with HBsAg loss over time. However, little is known
about their impacts on HBsAg loss in HBeAg-negative patients with limited
viral replication.

Methods:
A total of 688 HBeAg-negative patients with baseline serum HBV DNA levels
<2000 IU/mL were enrolled in Taiwan. The relationships of HBsAg and HBV DNA
levels with subsequent HBsAg loss were investigated.

Results:
In a mean follow-up of 11.6 years, the average annual rate of HBsAg loss
was 1.6%. Baseline HBsAg and HBV DNA levels were inversely associated with
subsequent HBsAg loss. When compared to patients with HBsAg levels >1000
IU/mL, the rates of HBsAg loss were significantly higher in patients with
HBsAg levels of 100-999, 10–99,  <10 IU/mL, with hazard ratios of 2.5 [95%
confidence interval (CI), 1.6–4.0], 2.8 (95% CI, 1.6-5.0), and 13.2 (95%
CI, 8.1–21.5), respectively. Multivariate analysis showed that HBsAg
level, but not HBV DNA, remained as an independent factor. The adjusted
hazard ratio of HBsAg loss was 13.2 (95% CI, 7.8-22.1) for HBsAg level<10
versus ≧1000 IU/mL. When compared to HBV DNA level by receiver operating
characteristic curve analysis, HBsAg level served as a better predictor of
both 5-year and 10-year HBsAg loss.

Conclusions:
In HBeAg-negative patients with HBV genotype B or C infection who have HBV
DNA <2000 IU/mL, HBsAg <10 IU/mL is the strongest predictor of HBsAg loss.
(HEPATOLOGY 2011.)

lin12345

谢谢分享