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标题: 有劳英语高手 [打印本页]

作者: garyfu 时间: 2011-6-11 11:14 标题: 有劳英语高手

哪位英语高手能把这篇报告的结论告诉给大家？http://www.ihlpress.com/pdf%20files/hepdart09_presentations/emergence_prevention_vr/5a_Gish_HBV%20HepDart%20Final%20A%20Retrospective%20Analysis%20of%20Tenofovir%20and%20Entecavir%20sub.pdf

作者: StephenW 时间: 2011-6-11 13:55

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A Retrospective Analysis of Tenofovir DF and Entecavir inPatients with Chronic Hepatitis B (CHB) and Previous Treatment Failure (PTF).

Conclusions

1. Combination entecavir and tenofovir DF treatment was effective in treating PTF (previous Treatment Failure) patients.

-Combination therapy was exceptionally well tolerated,with 4 adverse events associated with combination therapy due to a change increatinine clearance/GFR.

-All but one renal change resolved after dose adjustmentswere performed.

2. TDF+ETV Combo treatment was found to be more effective(as measured by time to DNA negativity) than ETV monotherapy.

-Analysis of medium time to DNAnegativity for both groups using non-parametric testing (Kruskal-Wallis) foundthe difference between the two arms to be significant at the 0.017 level.

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