治疗性疫苗和免疫疗法乙型肝炎：展望与挑战

StephenW

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Ongoing clinical trials
• Recombinant hepatitis B proteins (HBsAg+HBcAg), nasal immunization [30, 32];
• Preventive hepatitis B vaccine +/- Clevudine ( NCT00501124)
• DNA vaccines* + antiviral treatment (NCT00536627; NCT00513968; NCT01189656)
• Preventive hepatitis B vaccine (preS2/HBsAg vaccine) + IL-7 + Entecavir or
Tenofovir (NCT01027065)
• HBsAg/anti-HBs immune complexes¶ [84]乙克?

MP4

HBsAg/anti-HBs immune complexes=YIC乙克
TRC-00000019&TRC-00000022,乙克
NCT00536627,法国-巴斯德
NCT00513968,韩国-Genexine
NCT01189656,中国-广州药业-解放军458医院
NCT00869778,中国-重庆啤酒-解放军第三军医大学

StephenW

MP4 发表于 2011-1-29 21:39
HBsAg/anti-HBs immune complexes=YIC乙克
TRC-00000019&TRC-00000022,乙克
NCT00536627,法国-巴斯德

NCT00536627,法国-巴斯德-Naked DNA vaccine
NCT00513968,韩国-Genexine-mixed plasmid DNA (HB-110) combined with an antiviral agent (Adefovir)
NCT01189656,中国-广州药业-解放军458医院-Double-plasmid Hepatitis B Virus (HBV) DNA Vaccine
NCT00869778,中国-重庆啤酒-解放军第三军医大学-Synthesized Peptide

Any information about the "synthesized peptide"?

MP4

SHA:600132
www.chongqingbeer.com/view.asp?id=462

MP4

http://baike.baidu.com/view/64661.htm

StephenW

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peptide is just a short chain of amino acids (protein is a long chain of amino acids). So synthetic peptide can be anything. This vaccine seems to combine entecavir according to the website you supplied.
"以浙江大学医学院附属第一医院为中心实验室（组长单位）的"治疗用（合成肽）乙型肝炎疫苗联合恩替卡韦治疗慢性乙型肝炎患者的疗效及安全性的随机、双盲、多中心II期临床研究"临床试验正在进行受试者的筛选入组工作，目前累计已入组了336例受试者"。

MP4

现在有预防疫苗是基因重组蛋白+佐剂
合成肽可以理解为将基因重组蛋白再分解,将其中免疫原性较强的肽段保留,其它剔除...然后合成.

StephenW

MP4 发表于 2011-1-30 20:39
现在有预防疫苗是基因重组蛋白+佐剂
合成肽可以理解为将基因重组蛋白再分解,将其中免疫原性较强的肽段保留, ...

Thanks for the explanation. I think it is just a peptide that they find to be immunogenic. But is it combined with entecavir, some how? Or is the vaccine given at the same time with entecavir therapy?

StephenW

I have received a very kind reply from Professor Michel and a copy of her paper (the same as received by MP4 from Dr Deng) in pdf format. Anyone wishing a copy, please send me a short message and an email address, I will forward the copy to you. I also thank Professor Michel on behalf of all of us and wish her and her team a Happy Chinese New Year.

Dear Stephen
     Please find attached the requested paper
     note that its not the final version
     so don't diffuse it because  modifications regarding figures and some mistakes will be made
    I Will send the final one ASAP
     sincerely
     ML Michel

Dr. Marie-Louise MICHEL
Laboratoire de Pathogenèse des virus de l'hépatite B/ Institut Pasteur
INSERM U845
Unité de Pathogénèse des hépatites virales B et Immunothérapie
Département de Virologie
Bâtiment Lwoff
Institut Pasteur
28, rue du Docteur Roux
75724 PARIS CEDEX 15
Tel   33 1.45.68.88.49
Fax   33 1.40.61.38.41
cell +33 6 42 76 49 60
e-mail : [email protected]

Nouvelle adresse: [email protected]

我已经收到了米歇尔教授的答复和她的文件副本（相同如MP4收到来自邓博士）PDF格式。任何读者需要一个副本，请给我一个短信息，电子邮件地址，我会发送你的副本。
我也代表我们全体感谢米歇尔教授，并祝愿她和她的团队新年快乐。

史蒂芬
随信附上所需文件
请注意，它不是最后的版本
所以不要扩散，因为修改有关数字和一些就要犯错误
我会尽快发送最后版本-尽快

真诚
米歇尔毫升

玛丽博士，路易斯米歇尔
Laboratoire病毒德辅德Pathogenèse欧莱雅hépatite乙/巴斯德研究所
INSERM的U845
联合德Pathogénèse德hépatites virales乙等Immunothérapie
省的德Virologie
Bâtiment Lwoff
巴斯德研究所
28日，杜Docteur鲁街
75724巴黎Cedex的15
电话331.45.68.88.49
传真331.40.61.38.41
细胞336 427649 60
电子邮件：[email protected]


玛丽- louise.michel@ pasteur.fr

MP4

StephenW 发表于 2011-1-30 21:07
Thanks for the explanation. I think it is just a peptide that they find to be immunogenic. But is i ...

Is the vaccine given at the same time with entecavir therapy