成人非酒精性脂肪肝患者血清维生素 C 与肝纤维化的关系

StephenW

成人非酒精性脂肪肝患者血清维生素 C 与肝纤维化的关系
赵一普
ORCID Icon & 李海璐
第 872-877 页 | 2021 年 12 月 17 日收到，2022 年 2 月 5 日接受，在线发表：2022 年 2 月 21 日

    下载引文 https://doi.org/10.1080/00365521.2022.2041085 CrossMark Logo CrossMark

抽象的
客观的

本研究旨在调查美国成人 NAFLD 患者血清维生素 C 与肝纤维化之间的关系。
方法

我们对 2017 年至 2018 年全国健康和营养检查调查 (NHANES) 周期的数据进行了横断面分析。血清维生素 C 和瞬时弹性成像 (TE) 获得的肝脏硬度分别作为自变量和因变量。通过控制衰减参数（CAP）和TE检测肝脂肪变性和纤维化。 NAFLD 的定义是 CAP 评分≥248 dB/m，没有任何其他慢性肝病原因的迹象。 ≥8.2 kPa 的中位肝硬度用于识别 NAFLD 患者的显着纤维化（≥F2）。我们使用多变量逻辑回归模型计算了与显着 NAFLD 纤维化相关的调整优势比 (OR) 和 95% 置信区间 (CI)。
结果

总体而言，1926 名 NAFLD 患者被纳入分析，267 名受试者符合显着纤维化的定义。在调整潜在混杂因素后，血清维生素 C 与 NAFLD 肝纤维化的发生率降低相关（OR = 0.60，95% CI，0.43-0.84），而在按性别和体重指数（BMI）分层的亚组分析中，这种关联在调整混杂因素后显示出差异（男性：OR = 0.43, 95% CI, 0.26-0.71；女性：OR = 0.78, 95% CI, 0.49-1.24）。血清维生素 C 与体重过轻或正常的 NAFLD 中的肝纤维化没有显着相关性（OR = 1.34, 95% CI, 0.19-9.34）。
结论

这项横断面研究表明，血清维生素 C 与男性和超重或肥胖 NAFLD 患者的显着纤维化有关。

关键词：维生素CNAFLD肝纤维化控制衰减参数NHANES

StephenW

Association of serum vitamin C with liver fibrosis in adults with nonalcoholic fatty liver disease
Yipu Zhao
ORCID Icon & Hailu Li
Pages 872-877 | Received 17 Dec 2021, Accepted 05 Feb 2022, Published online: 21 Feb 2022

    Download citation https://doi.org/10.1080/00365521.2022.2041085 CrossMark Logo CrossMark

Abstract
Objective

This study aimed to investigate the association between serum vitamin C and liver fibrosis in patients with NAFLD in the US adults.
Methods

We conducted a cross-sectional analysis of data from the 2017 to 2018 cycle of National Health and Nutrition Examination Survey (NHANES). Serum vitamin C and transient elastography (TE)-accessed liver stiffness was taken as independent and dependent variables, respectively. Liver steatosis and fibrosis were detected by controlling attenuation parameter (CAP) and TE. NAFLD was defined by a CAP score of ≥248 dB/m without any indication of other causes of chronic liver disease. The median liver stiffness of ≥8.2 kPa was used to identify significant fibrosis (≥F2) among NAFLD patients. We calculated the adjusted odds ratio (OR) and 95% confidential intervals (CIs) for associations with significant NAFLD fibrosis using multivariable logistic regression models.
Results

Overall, 1926 individuals with NAFLD were included in the analysis and 267 subjects met the definition of significant fibrosis. Serum vitamin C was associated with lower odds of liver fibrosis in NAFLD after adjusting for potential confounders (OR = 0.60, 95% CI, 0.43–0.84), while in the subgroup analysis stratified by gender and body mass index (BMI), this association showed a difference after adjusting for confounders (males: OR = 0.43, 95% CI, 0.26–0.71; females: OR = 0.78, 95% CI, 0.49–1.24). There were no significant associations of serum vitamin C with liver fibrosis in NAFLD with underweight or normal (OR = 1.34, 95% CI, 0.19–9.34).
Conclusions

This cross-sectional study indicated an association of serum vitamin C with significant fibrosis in men and overweight or obese patients with NAFLD.

Keywords: Vitamin CNAFLDliver fibrosiscontrolled attenuation parameterNHANES