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发表于 2002-1-13 01:48
Z Gastroenterol 2001 Dec;39(12):1023-6
[MARS (Molecular Adsorbent Recycling System) as a novel hepatic
detoxification procedure until orthotopic liver transplantation].
[Article in German]
Ullerich H, Avenhaus W, Menzel J, Dietl KH, Domschke W, Lerch MM
Medizinische Klinik und Poliklinik B und. [email protected]
[Medline record in process]
MARS (Molecular Adsorbent Recycling System) as a novel hepatic
detoxification procedure until orthotopic liver transplantation.We report
the case of a 30-year-old man who was admitted because of acute liver
failure due to longstanding ethanol abuse. On conservative treatment liver
function progressively deteriorated and the patient was listed for
orthotopic liver transplantation. Because of a rapidly progressive and
clinically severe hepatic encephalopathy together with increasing bilirubin
levels (maximum 39 mg/dl) we began intermittent extracorporeal
detoxification with the Molecular Adsorbent Recycling System (MARS). Under
MARS therapy serum bilirubin decreased significantly (to 20 mg/dl after
three cycles) and encephalopathy improved rapidly until the patient was
completely oriented. No effect of MARS on liver function could be
demonstrated. MARS treatment was successfully continued until a cadaver
liver became available after 48 days and the patient was transplanted in
good clinical and neurological condition and without complications. MARS
represents a novel detoxification technique which, in patients with acute
liver failure, can successfully replace hepatic detoxification until
orthotopic liver transplantation can be performed.
PMID: 11753787, UI: 21625968
==================
Sheree Martin mailto:[email protected]
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