Are we giving too many doses of hepatitis A and B

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Are we giving too many doses of hepatitis A and B vaccines?Vaccine 2002 May 15;20(16):2017-8







Are we giving too many doses of hepatitis A and B vaccines?



Iwarson S

Department of Infectious Diseases, Sahlgrenska University Hospital, Ostra,

SE-416 85, Gothenburg, Sweden



[Medline record in process]





The immune response of an inactivated hepatitis A vaccine given to middle aged travellers 4-6 years after one single, primary dose was recently studied. All 25 vaccinees showed an impressive anamnestic booster response (GMT 2.993mIU/ml).The study confirms one previous report as well as experimental data, indicating a long-term proliferative T-cell response following one single primary dose of Havrix 1440.In 1999, Wistrom et al. demonstrated that a booster 4 years after priming medical students with one single dose of a recombinant HB vaccine disclosed a rapid antibody response

indicating a well-preserved memory. These reports put in focus the question: are we routinely offering too many doses of hepatitis A and B vaccines?



PMID: 11972968, UI: 21970336