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发表于 2007-8-6 04:26
呵呵，here we go again......sperm!
Father-to-Child Hepatitis B Transmission Documented in Japan
NEW YORK (Reuters Health) Jul 25 - Molecular evidence indicates that
father-to-child transmission is an "important route" of hepatitis B virus
(HBV) infection in Japan, Japanese researchers warn in the July issue of the
Journal of Medical Virology.
"At present, only high-risk infants born to chronic HBV-infected mothers are
given HBV vaccine," note Dr. Hitoshi Tajiri, of Osaka General Medical
Center, and colleagues. Their research, they say, provides "substantial
evidence" that fathers can and often do transmit HBV to their children.
Using homology analyses and phylogenetic analyses of two coding regions of
the HBV genome (the S and X gene), Dr. Tajiri's group showed that eight
children from five families contracted HBV from their fathers.
"The nucleotide homology among the five sets of fathers and children was
quite high (99.3-100%)," they report. "A phylogenetic tree constructed on
the 13 nucleotide sequences showed that all five sets of fathers and
children were grouped into the same cluster with high bootstrap values."
Based on their findings, Dr. Tajiri and colleagues "strongly" recommend that
Japan's public health agencies "re-examine the current policy of prevention
of HBV transmission for children as soon as possible so that universal
vaccination against HBV infection is immediately instituted in Japan for all
children, as WHO has recommended."
It's also "intriguing," they note, that all of the mothers from the five
families studied seemed to have contracted HBV infection, most likely via
sexual relations with their husbands, and were cured. All of them were
negative for hepatitis B surface antigen and positive for anti-HBV
antibodies at the time of the study.
This suggests that "spouses of HBV-infected husbands should also be
protected against HBV infection," the investigators write.
J Med Virol 2007;79:922-926.
http://www.medscape.com/viewarticle/560361?src=mp
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