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41楼
发表于 2008-5-15 11:41
原帖由 父母恩 于 2008-5-15 10:47 发表
我妈查抗体AMA-M2 阳性,是否可基本确诊为PBC?
两个月不到,5月7日,我妈又消化道出血了,这次白细胞和血小板指标都不正常了,
7日,白细胞 7.96 血小板 136 血红蛋白 96
8日,白细胞 5.30 血小板 95 血红蛋白 76
9日,白细胞 3 ...
可以,因为85.4%的PBC患者AMA-M2会阳性。应该尽快按照体重服用熊去氧胆酸(UDCA),因为AMA-M2阳性的患者更容易在生化,胆淤,免疫攻击等方面恶化快。
不用太在意那个血小板等数字,检查凝血,检查内镜预防首次出血等才重要。
文献:
Titre du document / Document title
Current understanding of primary biliary cirrhosis
Auteur(s) / Author(s)
ILCHENKO L. Yu. ; GOLOVANOVA E. V. ; TSAREGORODTSEVA T. M. ; SEROVA T. I. ; GUDKOVA R. B. ;
Résumé / Abstract
Aim. To examine characteristics of the course of primary biliary cirrhosis (PBC). Material and methods. The study of 150 PBC patients aged 26-82 years used clinical, biochemical, immunological and morphological methods. Results. Antimitochondrial antibodies of type M2 (AMAM2) were detected in 85.4% patients with PBC. A positive correlation was found between clinicobiochemical activity of the disease and number of AMAM2. AMAM2-positive patients more frequently had extrahepatic manifestations, overlap syndrome, higher biochemical and immunological activity vs AMAM2-negatlve patients. Conclusion. The following variants of PBC course were identified: classic AMAM2-positive, AMAM2-negative, overlapping of PBC and autoimmune hepatitis. Concentration of AMAM2 has diagnostic and prognostic value in PBC.
Revue / Journal Title
Terapevtičeskij arhiv ISSN 0040-3660
Source / Source
2005, vol. 77, no2, pp. 50-54 [5 page(s) (article)]
Langue / Language
Russe
Editeur / Publisher
Medicina, Moskva, RUSSIE, FEDERATION DE (1923) (Revue)
Mots-clés d'auteur / Author Keywords
primary biliary cirrhosis ; antimitochondrial antibodies ; overlap syndrome ;
Localisation / Location
INIST-CNRS, Cote INIST : 7283, 35400013807780.0120
Copyright 2007 INIST-CNRS. All rights reserved
Toute reproduction ou diffusion même partielle, par quelque procédé ou sur tout support que ce soit, ne pourra être faite sans l'accord préalable écrit de l'INIST-CNRS.
No part of these records may be reproduced of distributed, in any form or by any means, without the prior written permission of INIST-CNRS.
Nº notice refdoc (ud4) : 16849830 |
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