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肝胆相照论坛 论坛 学术讨论& HBV English 存档 1 Nitzoxanide 展示出抗乙肝病毒效力
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Nitzoxanide 展示出抗乙肝病毒效力

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发表于 2006-6-19 09:04

抗病毒在乙肝治疗中越来越普及,随之而来的病毒变异问题也越来越受关注,这迫使不断地研制新药。200年在美国洛杉矶举行的“消化疾病”会议报导,Nitzoxanide 展示出抗乙肝病毒效力。

Nitzoxanide 展示出抗乙肝病毒效力。

2006 6 18 星期日

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版主勋章 勤于助新 携手同心 文思泉涌 锄草勋章

发表于 2006-6-20 00:08
好像是种新药的名字,过去没有跟踪报道过。
未成小隐聊中隐,可得长闲胜暂闲。
我本无家更安往,故乡无此好湖山。

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发表于 2006-7-17 05:28
关注中
自助者天助,大家用实际行动消除歧视

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发表于 2006-7-17 09:08
中文名是什么?

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发表于 2006-7-17 22:01
第一次听说!但愿是我们的希望!请有良知有技术有专业敬业精神的研究人员加快研究步伐!早日解决这一人类难关!

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发表于 2006-7-18 10:04

有相关的报道吗?

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发表于 2006-7-18 12:18
不会是假的吧

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发表于 2006-7-21 20:24
Nitzoxanide Demonstrates In Vitro Activity Against HBV

Due to the emergence of resistant hepatitis B virus (HBV), researchers are continually seeking new drugs for the treatment of chronic hepatitis B, especially ones that work by novel mechanisms.

Nitazoxanide - an antimicrobial agent - in a new class known as thiazolides is approved in the United States for the treatment of gastroenteritis caused by Cryptosporidium parvum and Giardia lamblia, and is in the late stages of development for Clostridium difficile infection.

A preclinical study presented at the recent Digestive Disease Week 2006 conference in Los Angeles showed that nitazoxanide is also active against HBV in vitro, and potentially in patients as well.

Patient Results

The authors also administered the drug to a 48-year-old Egyptian man with HBeAg-positive chronic hepatitis B refractory to lamivudine. He received 500 mg twice-daily oral nitazoxanide with food for 24 weeks, with evaluations including physical examination, laboratory safety tests, and HBV DNA quantification performed every four weeks.

After 4 weeks of treatment, the patient experienced a 2 log reduction in HBV viral load (from 5,250,000 copies/mm3 at baseline to 51,000 copies/mm3).

He experienced a slight increase in ALT (from 53 IU/L at baseline to 60 IU/L).

At weeks 8, 12, 16, 20 and 24, the patient had seroconverted to HBeAg-negative and he had undetectable HBV DNA and normal ALT.

No significant adverse events were reported.


Conclusions
The researchers concluded that their results suggest that nitazoxanide is effective in treating chronic hepatitis B, with a mechanism of action that differs from those of traditional antiviral drugs. The treated patient is being followed to determine duration of response, and a double-blind placebo-controlled trial is underway.

6/16/06

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发表于 2006-7-21 21:17
英文啊,不懂,请好心人翻一下。

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发表于 2006-7-25 10:52
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