ETV长期治疗的LAM耐药者中极少数出现表型耐药(11.4 AASLD)

zasxz

After Long-term Entecavir Therapy, Phenotypic Resistance Emerges in a Small Number of Subjects Who Have Pre-existing Lamivudine Substitutions

The authors conclude, 揈TV phenotypic resistance emerges in a small number of subjects who have pre-existing LVDR substitutions after prolonged ETV therapy.

To date, two distinct resistance pathways have been identified, requiring multiple unique RT substitutions.

11/05/04 Reference T J Tenney and others. HEPATITIS B VIRUS RESISTANCE TO ENTECAVIR INVOLVES NOVEL CHANGES IN THE VIRAL POLYMERASE. Abstract 184 (poster). 55th AASLD.